PX-2025Thermosensitive Hyaluronic Gel With Octenidine for Periodontitis Treatment

This study is about testing the effectiveness of a thermosensitive hyaluronic gel with octenidine, known as PX-Gel, when used alongside scaling and root planing (SRP), a standard non-surgical treatment for periodontitis. The trial is specifically for adult patients with periodontitis stage II-III or IV, who have at least 20 existing teeth and a minimum of 4 pockets of 5 mm or more that bleed on probing. The goal is to see if PX-Gel can enhance gingival healing and reduce pocket depth when used as an adjunct to SRP. This is important as it could potentially improve the care and treatment outcomes for people suffering from periodontitis. During the study, each patient will have at least 4 sites with a pocket depth more than 5 mm and positive bleeding on probing in 2 contralateral quadrants. These sites will be randomly assigned to receive either the test treatment (SRP + PX-Gel) or serve as controls (SRP only). The treatment assignment will be concealed in opaque sealed envelopes and revealed only after the SRP session. The effectiveness of the treatment will be measured by the reduction in pocket depth, using a light probing force with a 1-mm periodontal probe at six sites around each tooth. Patients will not be informed where the treatment gel is applied. The study ensures blinding of the independent examiner throughout the study period.