Relationship Between Knee Osteoarthritis Severity and Fetuin-A and COMP Levels

This study focuses on knee osteoarthritis, a condition where the cartilage in the knee joint breaks down, leading to pain and inflammation. The research aims to understand the connection between the severity of knee osteoarthritis and the levels of two specific substances in the blood, known as Fetuin-A and Cartilage Oligomeric Matrix Protein (COMP). By studying these substances, healthcare providers may gain a better understanding of the disease, potentially enabling earlier diagnosis and improved tracking of disease progression. The study involves 120 individuals with knee osteoarthritis and 60 healthy volunteers without any history of joint disorders. Participants in this observational study will undergo radiographic evaluations to assess the severity of their knee osteoarthritis. They will also be asked to complete pain severity scales, mobility metrics, and functional questionnaires to evaluate the impact of the condition on their daily lives. Blood samples will be collected from all participants to measure the levels of Fetuin-A and COMP. The study will then analyze whether the levels of these substances in the blood are significantly linked with the severity of knee joint degeneration and functional impairment.