Nitrous Oxide Concentrations in Blood, Exhaled Air, and Urine After Different Exposures
This study aims to determine the time it takes for Nitrous Oxide to be detected in your blood after different levels of exposure.
Nitrous Oxide 99 %
+ Nitrous Oxide 99 %
+ Nitrous Oxide 99 %
Criminal Behavior+1
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+ Dangerous Behavior
Other Study
Summary
Study start date: June 1, 2026
Actual date on which the first participant was enrolled.This study focuses on understanding how much nitrous oxide, a type of gas, ends up in the blood, exhaled breath, and urine after different types of exposure. It looks at three scenarios: breathing in nitrous oxide from cartridges in a car, eating whipped cream made with nitrous oxide, and being exposed to it through work as a midwife in a delivery room. The goal is to see how these different situations might lead to varying levels of nitrous oxide in the body. This research is important as it can help us understand more about how nitrous oxide affects the body in different circumstances and potentially lead to improved safety measures. During the study, the levels of nitrous oxide in the blood and exhaled breath are checked for up to an hour after exposure. For urine, the checks continue for up to two hours. The blood and urine samples are tested using gas chromatography and mass spectrometry, while the breath is tested using a special sensor. One of the main things the study wants to find out is how long after exposure nitrous oxide can still be detected in the blood.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.40 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Other Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 18 to 65 Years
Range of ages for which participants are eligible to join.Healthy volunteers allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
For arm 1, 2, and 3: Inclusion Criteria: * Age 18-65 years * Able to understand Danish * Willing to use effective contraception for 24 hours after the end of exposure (oral contraceptives, contraceptive implant, transdermal patch, vaginal ring, or injectable contraceptives) * Written informed consent Exclusion Criteria: * Current or past abuse of drugs, nitrous oxide (N₂O), or alcohol * A psychiatric disorder requiring medical treatment, including severe depression * A diagnosis of epilepsy * Symptoms of peripheral neuropathy * Significant cardiac or pulmonary disease * Previous allergic or adverse reaction to N₂O * Diving within the past 2 days * Inability to refrain from diving for 2 days after the study * Occupational exposure to N₂O * Use of N₂O within the past 3 months * Treatment with methotrexate, benzodiazepines, opioids, or other centrally depressant drugs * Recent intraocular gas injection * Known impaired liver or kidney function * Pregnant or breastfeeding women (fertile women, defined as amenorrhea for less than 12 months, must have a negative hCG pregnancy test prior to receiving the study intervention)
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.4 intervention groups are designated in this study
This study does not include a placebo group
Treatment Groups
Group I
ExperimentalGroup II
ExperimentalGroup III
ExperimentalGroup IV
Active ComparatorStudy Objectives
Primary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location