Recruiting

Patient-Related Factors Influencing Greater Occipital Nerve Blockade Response in Medication-Overuse Headache

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Study Aim

This observational study aims to identify patient-related factors that influence the response to greater occipital nerve blockade in medication-overuse headache, by examining the number of days you use analgesics for headache in the past month.

What is being collected

Data Collection

Collected at a single point in time - Cross-sectional
Who is being recruted

Brain Diseases+7

+ Central Nervous System Diseases

+ Headache

From 18 to 65 Years
+13 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Case-Control

Comparing exposures between individuals with and without disease in order to identify potential risk factors.
Observational
Study Start: March 2026
See protocol details

Summary

Principal SponsorSultan 1. Murat State Hospital
Study ContactAlper Mengi, MD
Last updated: March 24, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: March 17, 2026

Actual date on which the first participant was enrolled.

This study focuses on understanding the factors that may affect the response to treatment in individuals with medication-overuse headache. This condition occurs when a person uses pain-relieving medication too often, causing the medicine to lose effectiveness and the headaches to become more frequent. The study specifically looks at patients who undergo a procedure called ultrasound-guided greater occipital nerve block, a treatment that involves injecting medication around the occipital nerves located at the back of the head to block pain signals. The goal is to identify pre-treatment patient characteristics that could influence the success of this procedure. During the study, participants will be asked about their use of pain-relieving medication for headaches over the past month. The primary outcome measured is the total number of days on which they used these analgesics. This information helps the researchers evaluate the effectiveness of the greater occipital nerve block in reducing the need for pain medication and potentially improving the quality of life for individuals with medication-overuse headache.

Official TitleFactors Affecting Treatment Response in Patients With Medication-Overuse Headache Undergoing Greater Occipital Nerve Blockade
Principal SponsorSultan 1. Murat State Hospital
Study ContactAlper Mengi, MD
Last updated: March 24, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

70 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Case-Control

These studies compare people who have a disease (cases) with those who don't (controls). The goal is to look back at previous exposures or risk factors to identify what might have contributed to the disease.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 65 Years

Range of ages for which participants are eligible to join.

Conditions

Pathology

Brain DiseasesCentral Nervous System DiseasesHeadacheNervous System DiseasesNeurologic ManifestationsPainSigns and SymptomsPathological Conditions, Signs and SymptomsHeadache DisordersHeadache Disorders, Secondary

Criteria

4 inclusion criteria required to participate
Age between 18 and 65 years

Diagnosis of medication-overuse headache associated with the use of triptans or nonsteroidal anti-inflammatory drugs

Previous diagnosis of chronic migraine or chronic tension-type headache according to the ICHD-3 criteria

Diagnosis of medication-overuse headache according to the International Classification of Headache Disorders, 3rd edition (ICHD-3)

9 exclusion criteria prevent from participating
History of substance abuse

Pregnancy or breastfeeding

History of an additional neurological disorder (e.g., cerebrovascular disease, multiple sclerosis)

Presence of a concomitant systemic disease that may affect quality of life (e.g., congestive heart failure, chronic kidney disease, chronic liver disease, pulmonary disease, uncontrolled diabetes, or peripheral vascular disease)

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Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

Sultan 1. Murat State Hospital

Edirne, Turkey (Türkiye)Open Sultan 1. Murat State Hospital in Google Maps
Recruiting
One Study Center