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Colistin Resistance Detection in Multi Drug Resistant Gram-negative Bacteria: Phenotypic and Genotypic Analysis

Study Aim

This observational study aims to evaluate the effectiveness of the disk elution test in detecting colistin resistance among multidrug-resistant gram-negative bacteria, compared to broth microdilution, and to identify such resistance through molecular detection using PCR.

What is being collected

Data Collection

Collected at a single point in time - Cross-sectional

Who is being recruted

+4 Eligibility Criteria

See all eligibility criteria

How is the trial designed

Other

Utilizing specific methods not covered by standard models in order to address unique research questions.

Observational

Study Start: August 2026

See protocol details

Summary

Principal SponsorAssiut University

Study Contactchristen william, Master's degree in clinic path

Last updated: March 24, 2026

Sourced from a government-validated database.Claim as a partner

Study start date: August 1, 2026

Actual date on which the first participant was enrolled.

This study focuses on the detection of colistin resistance among multidrug-resistant gram-negative bacteria in Assiut University Hospital. Colistin is an antibiotic used to treat infections caused by these bacteria. The study aims to compare the effectiveness of a routine method called the disk elution test with the broth microdilution method in detecting colistin resistance. Additionally, the study seeks to understand the genetic basis of colistin resistance in these bacteria. This research is important as it can help improve the diagnosis and treatment of infections caused by multidrug-resistant bacteria, a growing concern in healthcare today.

Official TitlePhenotypic and Genotypic Detection of Colistin Resistance Among Multi Drug Resistant Gram-negative Bacteria in Assiut University Hospital

NCT07487116

Principal SponsorAssiut University

Study Contactchristen william, Master's degree in clinic path

Last updated: March 24, 2026

Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Design Details

90 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Other

Some studies use unique or mixed approaches that don't fit standard categories. These may include innovative observational methods or studies tailored to specific research questions.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.

Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

1 inclusion criteria required to participate

Multidrug-resistant gram-negative isolates will be collected from clinical specimens (blood, urine, sputum, wound swabs, etc.) obtained from hospitalized patients in Assiut University Hospitals

3 exclusion criteria prevent from participating

gram-positive bacteria

carbapenem-sensitive gram-negative bacteria

repeated sample for same patient or different samples from the same patient

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has no location dataSave this study to your profile to know when the location data is available.

Recruiting soonNo study centers