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MTA vs Biodentine in Symptomatic Irreversible Pulpitis Treatment

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Study Aim

This study aims to compare the short-term effectiveness of MTA and Biodentine in treating symptomatic irreversible pulpitis through a complete pulpotomy procedure, measuring clinical outcomes with Electric Pulp Testing and radiographic outcomes with the Periapical Index.

What is being tested

Biodentine pulpotomy

Other
Who is being recruted

From 18 to 40 Years
+11 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: November 2024
See protocol details

Summary

Principal SponsorDow University of Health Sciences
Study ContactDr Khadija Zubair, Postgraduate trainee- FCPS
Last updated: March 20, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: November 2, 2024

Actual date on which the first participant was enrolled.

This study focuses on individuals who visit the Operative Dentistry Department with pain in their back teeth. The main goal is to compare the short-term results of two different materials, MTA and Biodentine, used in a procedure called complete pulpotomy. This procedure is typically performed when the pulp, the soft part inside the tooth, is infected and causing pain. The study aims to find out which material is more effective in treating this condition, potentially improving dental care for those suffering from symptomatic irreversible pulpitus. During the study, participants will have their medical and dental history recorded, and the affected tooth will be thoroughly examined. The procedure will be performed by a single dentist in two visits. After numbing the area with an injection, the dentist will remove the infected pulp and apply either MTA or Biodentine inside the tooth. A temporary filling will be placed, and the participant will return the next day for a final filling. An X-ray will be taken to check the result. Participants may take ibuprofen if they experience pain afterwards, and are asked to return for follow-ups after 1 day, 1 week, 1 month, and 3 months. The success of the treatment will be evaluated through electric pulp testing and radiographic outcome measure using a Periapical Index.

Official TitleShort Term Outcome of Complete Pulpotomy Using MTA vs Biodentine in Symptomatic Irreversible Pulpitis - A Randomized Controlled Trial
Principal SponsorDow University of Health Sciences
Study ContactDr Khadija Zubair, Postgraduate trainee- FCPS
Last updated: March 20, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

60 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 40 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

6 inclusion criteria required to participate
Age between 18-40 years of both males and females

Carious exposed maxillary and mandibular molars teeth

Moderate to severe pain (VAS 4-10)

Diagnosed with Symptomatic irreversible pulpitis on cold test and Electric pulp test (EPT)

Show More Criteria

5 exclusion criteria prevent from participating
Non-restorable carious lesion

Internal or external Resorption

Calcified canals

Any traumatic injury

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Pulpotomy material Biodentine

Group II

Experimental
Pulpotomy material MTA

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 2 locations

Recruiting

Dr Khadija Zubair

Karachi, PakistanOpen Dr Khadija Zubair in Google Maps
Recruiting

Dr Khadija Zubair

Karachi, Pakistan
Recruiting
2 Study Centers
MTA vs Biodentine in Symptomatic Irreversible Pulpitis Treatment | PatLynk