Topical Timolol Eye Drops vs Intense Pulsed Light for Post-Acne Erythema
This early phase 1 study aims to compare the effectiveness of topical Timolol eye drops and intense pulsed light therapy in reducing the severity and number of post-acne erythema lesions on the face.
Timolol 0.5% Ophthalmic Solution
+ Intense Pulsed Light
Acne Vulgaris+6
+ Erythema
+ Sebaceous Gland Diseases
Other Study
Summary
Study start date: March 9, 2026
Actual date on which the first participant was enrolled.Post-inflammatory erythema (PIE) is a common condition that can occur after acne vulgaris, causing red marks on the skin due to widened blood vessels. While current treatments like intense pulsed light (IPL) can help, they can be expensive and need special equipment. This study focuses on a different approach, using a medication called Timolol, a non-selective beta-adrenergic receptor blocker. Timolol has been shown to narrow blood vessels and has been used in dermatology for conditions related to blood vessels. The goal of this study is to evaluate the effectiveness and safety of a 0.5% Timolol eye drop solution in improving redness left by acne and to compare it with intense pulsed light (IPL) therapy. This research could provide evidence for a more cost-effective and accessible treatment option for managing redness after acne. During this study, participants will use either the Timolol eye drops or undergo IPL therapy. The changes in the severity of redness will be assessed using standard clinical evaluation and objective measurement tools over a specified treatment period. The severity of redness will be measured using the Clinician Erythema Assessment (CEA) scale, which ranges from 0 (clear) to 4 (severe redness). Additionally, the number of red marks on the face will be counted by a dermatologist during clinical examinations.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.60 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Other Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.Over 12 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.2 intervention groups are designated in this study
This study does not include a placebo group
Treatment Groups
Group I
ExperimentalGroup II
Active ComparatorStudy Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
Ho Chi Minh City Hospital of Dermato-Venereology
Ho Chi Minh City, VietnamOpen Ho Chi Minh City Hospital of Dermato-Venereology in Google Maps