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Intradermal Mesenchymal Stem Cell-Derived Exosome Therapy for Facial Skin Quality Improvement

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Study Aim

This study aims to evaluate the effectiveness of Intradermal Mesenchymal Stem Cell-Derived Exosome Therapy in improving facial skin quality, by measuring changes in various skin parameters such as wrinkles, skin texture, pore size, and UV spots, among others, over a six-month period.

What is being tested

Mesenchymal Stem Cell-Derived Exosome

Biological
Who is being recruted

From 18 to 65 Years
+13 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 3
Interventional
Study Start: April 2026
See protocol details

Summary

Principal SponsorMert Ersan
Study Contacthilal aybüke yıldız, MDMore contacts
Last updated: March 13, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: April 1, 2026

Actual date on which the first participant was enrolled.

This clinical study focuses on understanding the effects of a specific treatment on facial skin quality. The treatment involves injecting a preparation made from mesenchymal stem cell-derived exosomes just under the skin. Adults participating in this study will receive three treatment sessions, each a month apart. The importance of this study lies in its potential to improve facial skin characteristics and address related concerns, offering a new approach to skin care. During the study, participants' facial skin will be analyzed using a standardized imaging system called VISIA. This system captures detailed images of the skin and measures various aspects such as wrinkles, skin texture, pore size, and spots caused by sun exposure. These measurements will be taken at the start of the study, before each treatment, and six months after the final treatment. The main goal is to see how the treatment affects the overall skin quality, as measured by the VISIA system. Secondary goals include understanding the impact on specific skin features like wrinkles, skin texture, and spots.

Official TitleObjective Analysis of the Effects of Intradermally Administered Mesenchymal Stem Cell-Derived Suspended Exosome Therapy on Facial Skin Quality Using a Standardized Imaging System
NCT07466953
Principal SponsorMert Ersan
Study Contacthilal aybüke yıldız, MDMore contacts
Last updated: March 13, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

30 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 65 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

5 inclusion criteria required to participate
Adults aged 18 to 65 years
Individuals presenting facial skin aging signs
Willingness to undergo three intradermal treatment sessions
Ability to comply with study visits and follow-up assessments
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8 exclusion criteria prevent from participating
Active malignancy or ongoing cancer treatment
Pregnancy or breastfeeding
Active skin infection, inflammatory skin disease, or open wounds in the treatment area
History of allergic reactions to injectable dermatologic treatments
Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Participants will receive intradermal administration of mesenchymal stem cell-derived suspended exosome preparation in three treatment sessions performed at one-month intervals. Facial skin analysis will be conducted using the VISIA imaging system before each treatment session and six months after the final treatment.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.
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