PVI-Guided Acute Normovolemic Hemodilution for Precise Volume Management in Cardiac Surgery
This study aims to manage fluid volume precisely during cardiac surgery by using PVI-guided acute normovolemic hemodilution, focusing on the amount of crystalloid used during the procedures.
acute normovolemic hemodilution
+ PVI dependant acute normovolemic hemodilution
Pathologic Processes
+ Postoperative Complications
+ Pathological Conditions, Signs and Symptoms
Basic Science Study
Summary
Study start date: November 1, 2025
Actual date on which the first participant was enrolled.This study focuses on a blood conservation strategy called Acute Normovolemic Hemodilution (ANH). ANH is used during surgeries to reduce blood loss and the need for donor blood transfusions. It involves taking a certain amount of blood from the patient before surgery and replacing it with fluids, so the blood lost during surgery has less red blood cells. After surgery, the patient's own blood is returned to them. The study aims to improve this process for heart surgery patients by using a measure called the Pleth Variability Index (PVI). PVI helps doctors understand how well a patient's blood vessels are filled with fluid. The goal is to make ANH safer and more effective, potentially reducing the need for donor blood and complications related to surgery. During the study, participants undergoing heart surgery will have their ANH process guided by PVI. This means doctors will use PVI to decide how much fluid to give the patient. The main goal is to manage the patient's fluid levels more precisely. The study will measure this by looking at the amount of a specific type of fluid, called crystalloid, used during the surgery. The study also aims to find out if using PVI can reduce the need for donor blood transfusions and lower the risk of complications after surgery.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.80 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Basic Science Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 18 to 85 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.2 intervention groups are designated in this study
This study does not include a placebo group
Treatment Groups
Group I
Active ComparatorGroup II
ExperimentalStudy Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location