COMPAIRComparison of Budesonide and Formoterol Delivered With Symbicort Aerosphere® and Symbicort® pMDI in Children With Asthma

This study is a phase 1 trial that aims to compare the effectiveness of two different inhalers, Symbicort Aerosphere® and Symbicort® pMDI, in children aged 4 to less than 12 years who have asthma. The inhalers contain the same medications, Budesonide and Formoterol, but they deliver the medicine in slightly different ways. The goal of this study is to understand which inhaler works better for children in this age group, helping to improve asthma treatment options for them. During the study, participants are randomly assigned to two groups. One group will use Symbicort Aerosphere® first, and the other group will use Symbicort® pMDI first. Each child will receive two puffs from their assigned inhaler. After a gap of 28 to 42 days, the groups will switch, and the children who first used Symbicort Aerosphere® will now use Symbicort® pMDI, and vice versa. The study measures how much of the medication reaches the bloodstream and how quickly it gets there. This helps to determine which inhaler is more effective at delivering the medication to the body.