Completed

Miswak vs. Toothbrush in Plaque Removal for Children

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Study Aim

This study aims to compare the effectiveness of Miswak and Toothbrush in removing plaque in children, using the Simplified Oral Hygiene Index as the primary measure.

What is being tested

Miswak

+ Toothbrush

Other
Who is being recruted

Dental Caries+1

+ Stomatognathic Diseases

+ Tooth Diseases

From 6 to 14 Years
+5 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Prevention Study

Interventional
Study Start: September 2025
See protocol details

Summary

Principal SponsorKing Abdulaziz University
Last updated: February 14, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: September 12, 2025

Actual date on which the first participant was enrolled.

This study aims to compare the effectiveness of a 45°-cut Miswak stick and a regular toothbrush in removing plaque from children's teeth. Miswak, a natural tooth-cleaning twig, offers both mechanical and chemical cleaning benefits. Its fibrous structure helps scrub away debris, while natural compounds like fluoride and silica contribute to its cavity-fighting properties. This research focuses on children aged 6 to 14, with the goal of finding an affordable and effective oral hygiene solution, particularly for children in underserved or resource-limited communities. In this split-mouth clinical trial, each child uses a Miswak stick on one side of their mouth and a toothbrush on the other side. This approach allows for a direct comparison within each child's mouth, reducing variability and enhancing the reliability of the results. The study measures the plaque index score using the Simplified Oral Hygiene Index (OHI-S) to assess which method is more effective in reducing plaque. Half of the children use the toothbrush on the left side and the Miswak on the right, while the other half follows the reverse assignment.

Official TitleEffectiveness of a 45°-Cut Miswak (Salvadora Persica) Versus a Toothbrush in Plaque Removal Among Children: A Randomized Split-Mouth Clinical Trial
NCT07409610
Principal SponsorKing Abdulaziz University
Last updated: February 14, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

82 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Prevention Study

Prevention studies aim to stop a disease from developing. They often involve people at risk and test things like vaccines, lifestyle changes, or preventive medications.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 6 to 14 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Dental CariesStomatognathic DiseasesTooth DiseasesTooth Demineralization

Criteria

2 inclusion criteria required to participate
Healthy children aged 6 to 14 years.

Children who their parents/legal guardians have approved and signed the consent form, which ensures that the participants are within the target age range and are healthy, which helps to control variables that could affect oral hygiene outcomes.

3 exclusion criteria prevent from participating
Children whose ages are below 6 years or above 14 years

Unhealthy children

Children with orthodontic brackets because it can affect oral hygiene practices and outcomes, excluding these participants ensures a more homogeneous sample.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
This arm introduces a 45° miswak technique, which aligns with the modified Bass method by angling the miswak fibers at 45° toward the gingival margin

Group II

Active Comparator
Participants in this arm used the modified bass technique using normal tooth brush and tooth paste

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

King Abdulaziz university

Jeddah, Saudi ArabiaOpen King Abdulaziz university in Google Maps
CompletedOne Study Center