MAP-ENDEarly Neurovascular Decoupling Trajectories in Acute Ischemic Stroke Patients After Revascularization

This study focuses on understanding the recovery process after a successful revascularization treatment for acute ischemic stroke, a condition caused by blockages in blood vessels leading to the brain. Despite successful treatment, patients often experience varying levels of functional recovery, which is not well understood. The study aims to explore the changes in the brain's blood flow and neural activity connection, known as neurovascular coupling, in the early days after treatment. It is believed that these changes may impact the patient's long-term recovery. The study will observe adult patients who have undergone successful endovascular thrombectomy within 24 hours of stroke symptoms. During the study, participants will undergo multimodal monitoring, which includes Transcranial Doppler (TCD), Electroencephalography (EEG), and F-wave studies. These tests measure cerebral hemodynamic status, cortical neuroelectrical activity, and spinal anterior horn motoneuron excitability, respectively. The study will track these measurements at different time points: within 24-72 hours post-thrombectomy, at Day 7, and at Day 90. The goal is to identify patterns in these measurements that can predict a patient's functional outcome 90 days after the stroke.