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Herbal Mouthwash vs. Chlorhexidine for Plaque Control in Gingivitis

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Study Aim

This study aims to compare the effectiveness of an herbal mouthwash versus Chlorhexidine in reducing plaque accumulation in individuals with gingivitis, measured by the plaque index.

What is being tested

Chlorhexidine 0,12%

+ herbal Mouthwash

Drug
Who is being recruted

Gingival Diseases+3

+ Gingivitis

+ Infections

Over 20 Years
+7 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 3
Interventional
Study Start: February 2026
See protocol details

Summary

Principal SponsorCairo University
Last updated: February 11, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: February 1, 2026

Actual date on which the first participant was enrolled.

Gingivitis, a common oral disease, can advance to a more severe condition called periodontitis if left untreated. The main cause of gingivitis is oral plaque, which is typically managed through professional dental cleaning and personal oral hygiene practices. While chlorhexidine mouthwash is considered the best option for oral rinses, its side effects necessitate the search for a safer and more tolerable alternative. This study introduces a homemade herbal mouthwash as a potential substitute, aiming to improve gingivitis treatment and meet the need for a more acceptable mouthwash. Participants in this study will use either the homemade herbal mouthwash or chlorhexidine. The effectiveness of each mouthwash is determined by measuring plaque accumulation on the teeth using a probe. The number of sites with plaque buildup is divided by the total number of dental sites to calculate the percentage of plaque accumulation. This comparison helps evaluate the potential of the herbal mouthwash as a safer and more comfortable alternative to chlorhexidine for managing gingivitis.

Official TitleThe Effect of Homemade Herbal Mouthwash Versus Chlorhexidine on Plaque Accumulation in Gingivitis. A Randomized Clinical Trial.
Principal SponsorCairo University
Last updated: February 11, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

12 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 20 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Gingival DiseasesGingivitisInfectionsStomatognathic DiseasesMouth DiseasesPeriodontal Diseases

Criteria

1 inclusion criteria required to participate
Plaque-induced gingivitis.

6 exclusion criteria prevent from participating
History of medications.

Medically compromised.

Pregnant females.

Periapical involvement in teeth.

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Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Active Comparator

Group II

Experimental

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.
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