Comparison of Periprosthetic Joint Infection Incidence and Microbial Profiles in Obese vs Non-Obese Patients After Total Knee Arthroplasty

This study focuses on understanding the risk of joint infection after a knee replacement surgery, specifically comparing obese and non-obese patients. The research aims to determine if obesity increases the likelihood of a periprosthetic joint infection (PJI) within two years following the surgery. By identifying the microbial profiles in obese patients, the study hopes to aid in selecting appropriate preventive measures and tailoring antibiotic treatments for this group. This research is important as it could lead to improved care for obese patients undergoing knee replacement surgery. The study involves adult patients with primary or secondary osteoarthritis who have undergone knee replacement surgery between 2011 and 2021. Patients are categorized into two groups based on their Body Mass Index (BMI): obese and non-obese. The primary outcome of interest is revision due to prosthetic joint infection within 730 days following surgery. Secondary outcomes include revision due to all causes within the same timeframe and the type of microbial infection in both obese and non-obese patients within the first 90 days and from 91 days to 730 days post-surgery. The study will use statistical analyses to compare the results between the two groups, taking into account factors such as age, sex, education, income, and comorbidities.