Comparative Study of Zinc Oxide Eugenol and Metapex in Primary Molar Root Canals
This study compares the effectiveness of zinc oxide eugenol and Metapex in the treatment of primary molar root canals, by measuring the degree of root resorption using Cone Beam Computed Tomography (CBCT).
Manual Instrumentation
+ Iodoform-Calcium Hydroxide (Metapex)
+ Zinc Oxide Eugenol (ZOE)
Treatment Study
Summary
Study start date: February 15, 2026
Actual date on which the first participant was enrolled.The study focuses on the importance of preserving primary teeth in children for proper chewing, speech development, and maintaining the arch structure. When these teeth get infected or damaged, a procedure called pulpectomy is often performed. This study compares two materials used in this procedure: Zinc Oxide Eugenol (ZOE) and Metapex, a mix of iodoform-calcium hydroxide. The goal is to find which material works better, considering factors like how well they fight bacteria, seal the tooth, and how quickly they break down naturally. This research is crucial as it aims to improve the effectiveness and safety of pulpectomy, ultimately enhancing children's oral health. In this study, 44 primary molars from children aged 5 to 8 will be divided into four groups. Each group will receive a different combination of treatment: either ZOE or Metapex, and either manual or rotary instrumentation for the procedure. The children's progress will be evaluated through clinical assessments like pain, tooth mobility, and sensitivity, and radiographic evaluations using CBCT scans at baseline, 6, and 12 months. The main outcome is to measure the success of the treatment through the resorption of the tooth root and bone healing. The results are expected to provide guidance on the best material and technique to use for pulpectomy in children, leading to more efficient and effective treatments.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.44 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 5 to 8 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Criteria
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.4 intervention groups are designated in this study
This study does not include a placebo group
Treatment Groups
Group I
ExperimentalGroup II
Active ComparatorGroup III
ExperimentalGroup IV
Active ComparatorStudy Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
Faculty of Dentistry, MSA University
Giza, EgyptOpen Faculty of Dentistry, MSA University in Google Maps