Completed

VATSUltrasound-Guided Erector Spinae Plane Block for Postoperative Pain Management in Obese Patients After Video-Assisted Thoracoscopy

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Study Aim

This study aims to evaluate the effectiveness of Ultrasound-Guided Erector Spinae Plane Block for managing postoperative pain in obese patients after Video-Assisted Thoracoscopy, specifically focusing on the time to first rescue analgesia during the first 24 hours post-operation.

What is being tested

Erector Spinae (ESP) Block with Bupivacaine (Marcaine®)

Procedure
Who is being recruted

From 18 to 60 Years
+16 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 4
Interventional
Study Start: July 2025
See protocol details

Summary

Principal SponsorZagazig University
Last updated: February 6, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: July 8, 2025

Actual date on which the first participant was enrolled.

This clinical trial aims to compare the safety and effectiveness of two different methods for managing pain after a type of lung surgery called video-assisted thoracoscopy in obese patients. The two methods are Ultrasound-Guided Erector Spinae Plane Block (ESPB) and intravenous nalbuphine. The ESPB is a less invasive regional anesthesia technique that involves injecting a local anesthetic into a specific area of the back, while nalbuphine is a pain relief medication given through a vein. The study is important because adequate pain management after surgery can help prevent respiratory complications and improve recovery. The trial will include 102 patients who are planned for video-assisted thoracoscopy and meet certain criteria. During the trial, patients will be randomly assigned to either the ESPB group or the nalbuphine group. Patients in the ESPB group will receive the local anesthetic injection after the surgery, while patients in the nalbuphine group will receive the pain relief medication through a vein. The study will measure the total amount of nalbuphine used in the first 24 hours after surgery, the time until the first dose of rescue pain medication is needed, and the intensity of pain at rest and during movement. The study will also evaluate side effects related to the use of opioids, such as sedation, itching, and respiratory depression, as well as patient satisfaction with their pain management.

Official TitleUltrasound-Guided Erector Spinae Plane Block Versus Intravenous Nalbuphine for Postoperative Analgesia After Video-assisted Thoracoscopy in Obese Patients: A Randomized Controlled Trial of Safety and Effectiveness
Principal SponsorZagazig University
Last updated: February 6, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

102 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.


Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 60 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

3 inclusion criteria required to participate
age between 21 years and 60 years

BMI (body mass index) between 30 and 40 kg/ m2

American Society of Anesthesiologist (ASA) status of II and III,

13 exclusion criteria prevent from participating
suffering from any bleeding disorders

chronic pain with regular use of either opioids or gabapentinoids during the 2 weeks before surgery

taking anticoagulation

pregnancy

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Active Comparator
Participants in this group receive an Ultrasound-guided Erector Spinae Plane Block (ESPB) along with multimodal analgesia. The ESPB is performed using Bupivacaine (Marcaine®) to help manage pain.

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

ZagazigU

Zagazig, EgyptOpen ZagazigU in Google Maps
CompletedOne Study Center