Recruiting soon

Apple Cider Vinegar Supplementation Impact on Urine Chemistry in Adults

Study Aim

This study aims to evaluate how daily apple cider vinegar supplementation affects the chemistry of your urine, specifically measuring changes in calcium, calcium oxalate, citrate, and urine pH.

What is being tested

Apple Cider Vinegar

Dietary Supplement

Who is being recruted

Urogenital Diseases+10

+ Calculi

+ Female Urogenital Diseases and Pregnancy Complications

Over 18 Years

+7 Eligibility Criteria

See all eligibility criteria

How is the trial designed

Supportive Care Study

Interventional

Study Start: March 2026

See protocol details

Summary

Principal SponsorUniversity of Chicago

Study ContactLuke Reynolds

Last updated: February 6, 2026

Sourced from a government-validated database.Claim as a partner

Study start date: March 1, 2026

Actual date on which the first participant was enrolled.

This study focuses on understanding how apple cider vinegar (ACV) supplementation affects urine chemistry. The research involves healthy individuals and those with kidney stones. The goal is to determine if a two-week course of daily ACV intake can cause significant changes in urine chemistry. This study is important because it may provide insights into whether ACV can be used as a supportive care measure for those with kidney stones or those at risk of developing them. During this study, participants are required to take ACV supplements daily for two weeks. The study measures changes in various components of urine, including calcium, calcium oxalate, citrate, and urine pH. These measurements help evaluate the impact of short-term daily ACV supplementation on urine chemistry. The potential risks and benefits of ACV supplementation will also be monitored throughout the study.

Official TitleThe Effect of Apple Cider Vinegar Supplementation on 24-hour Urine Chemistry in Adults

NCT07389226

Principal SponsorUniversity of Chicago

Study ContactLuke Reynolds

Last updated: February 6, 2026

Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Design Details

30 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Supportive Care Study

These studies explore ways to improve comfort and daily life for people living with a condition. They may focus on easing symptoms, reducing treatment side effects, or supporting overall well-being.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.

Conditions

Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Urogenital DiseasesCalculiFemale Urogenital Diseases and Pregnancy ComplicationsKidney CalculiKidney DiseasesPathological Conditions, Signs and SymptomsUrinary CalculiUrologic DiseasesPathological Conditions, AnatomicalFemale Urogenital DiseasesMale Urogenital DiseasesUrolithiasisNephrolithiasis

Criteria

3 inclusion criteria required to participate

Controls: Adults above the age of 18.

Kidney stone patients: Adults above the age of 18.

History of majority (>50%) calcium oxalate kidney stones

4 exclusion criteria prevent from participating

Any individual who has a history of a negative reaction (increased acid reflux, allergy) to ACV will also be excluded.

Anyone with a history of calcium phosphate stones (>50% calcium phosphate), uric acid stones, struvite stones, recent urinary tract instrumentation (<30 days), or recurrent urinary tract infections.

Any individual who has had ACV outside of normal consumption in the prior month will be excluded.

Any individual with chronic kidney disease, underlying acid base disorder will also be excluded.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.

Treatment Groups

Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group

Treatment Groups

Group I

Experimental

Participants will take Goli Apple Cider Vinegar gummies daily for 14 days, along with completing a 24-hour urine collection and 48-hour food diary.

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

The University of Chicago

Chicago, United StatesOpen The University of Chicago in Google Maps

Recruiting soonOne Study Center