Phenol Neurolysis vs Radiofrequency Thermocoagulation for Knee Arthroplasty Pain
This study compares the effectiveness of Phenol Neurolysis and Radiofrequency Thermocoagulation in reducing pain for individuals who have undergone knee arthroplasty surgery for chronic knee osteoarthritis, measuring success as a decrease of 50% or more in the Numerical Rating Scale (NRS) at 1, 3, and 6 months after the procedure.
genicular nerve radiofrequency thermocoagulation and fenole neurolysis
Arthritis+3
+ Joint Diseases
+ Musculoskeletal Diseases
Treatment Study
Summary
Study start date: September 15, 2025
Actual date on which the first participant was enrolled.This study focuses on comparing two methods for managing pain in individuals who have undergone knee replacement surgery due to chronic knee osteoarthritis. The two methods are Phenol Neurolysis and Radiofrequency Thermocoagulation, both applied to the geniculate nerve. The study involves 140 patients who will be evaluated at Adnan Menderes University Hospitals. It's important to note that all participants must be over 18 years old and have undergone knee arthroplasty for chronic knee osteoarthritis. The study aims to find a more effective method to manage post-surgery pain, potentially improving the quality of life for individuals with knee osteoarthritis. During the study, patients will be positioned comfortably and the procedures will be performed in a sterile environment. For the Radiofrequency Thermocoagulation group, a special cannula will be used to deliver the treatment to each geniculate nerve. In the Phenol Neurolysis group, a different type of needle will be used to inject a mixture of bupivacaine and phenol into each geniculate nerve. The effectiveness of both methods will be measured by the reduction in pain at 1, 3, and 6 months after the procedure. A decrease in pain of 50% or more will be considered significant. Any complications or side effects after the procedure will also be recorded.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.140 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.Healthy volunteers allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.2 intervention groups are designated in this study
This study does not include a placebo group
Treatment Groups
Group I
ExperimentalGroup II
ExperimentalStudy Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location