Suspended

Phenol Neurolysis vs Radiofrequency Thermocoagulation for Knee Arthroplasty Pain

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Study Aim

This study compares the effectiveness of Phenol Neurolysis and Radiofrequency Thermocoagulation in reducing pain for individuals who have undergone knee arthroplasty surgery for chronic knee osteoarthritis, measuring success as a decrease of 50% or more in the Numerical Rating Scale (NRS) at 1, 3, and 6 months after the procedure.

What is being tested

genicular nerve radiofrequency thermocoagulation and fenole neurolysis

Procedure
Who is being recruted

Arthritis+3

+ Joint Diseases

+ Musculoskeletal Diseases

+2 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: September 2025
See protocol details

Summary

Principal SponsorAydin Adnan Menderes University
Last updated: February 3, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: September 15, 2025

Actual date on which the first participant was enrolled.

This study focuses on comparing two methods for managing pain in individuals who have undergone knee replacement surgery due to chronic knee osteoarthritis. The two methods are Phenol Neurolysis and Radiofrequency Thermocoagulation, both applied to the geniculate nerve. The study involves 140 patients who will be evaluated at Adnan Menderes University Hospitals. It's important to note that all participants must be over 18 years old and have undergone knee arthroplasty for chronic knee osteoarthritis. The study aims to find a more effective method to manage post-surgery pain, potentially improving the quality of life for individuals with knee osteoarthritis. During the study, patients will be positioned comfortably and the procedures will be performed in a sterile environment. For the Radiofrequency Thermocoagulation group, a special cannula will be used to deliver the treatment to each geniculate nerve. In the Phenol Neurolysis group, a different type of needle will be used to inject a mixture of bupivacaine and phenol into each geniculate nerve. The effectiveness of both methods will be measured by the reduction in pain at 1, 3, and 6 months after the procedure. A decrease in pain of 50% or more will be considered significant. Any complications or side effects after the procedure will also be recorded.

Official TitleComparison of the Efficacy of Phenol Neurolysis and Radiofrequency Thermocoagulation Applied to the Geniculate Nerve on Pain in Patients Undergoing Knee Arthroplasty Surgery
Principal SponsorAydin Adnan Menderes University
Last updated: February 3, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

140 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

ArthritisJoint DiseasesMusculoskeletal DiseasesOsteoarthritisRheumatic DiseasesOsteoarthritis, Knee

Criteria

1 inclusion criteria required to participate
Patients over the age of 18 who had undergone arthroplasty for chronic knee osteoarthritis.

1 exclusion criteria prevent from participating
Patients with severe systemic diseases, local infections or injuries, and those allergic to any of the injection materials were excluded from the study.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
patients to whom applied radiofrequency thermocoagulation

Group II

Experimental
patients to whom applied chemical neurolysis

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Esra Ertilav

Aydin, Turkey (Türkiye)Open Esra Ertilav in Google Maps
SuspendedOne Study Center
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