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TMS Impact on LH and FSH Hormones in Healthy Women

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What is being tested

Transcranial Magnetic Stimulation Active

+ Transcranial Magnetic Stimulation Sham

Device
Who is being recruted

From 22 to 40 Years
+18 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Basic Science Study

Placebo-Controlled
Interventional
Study Start: February 2026
See protocol details

Summary

Principal SponsorThe City College of New York
Study ContactKyle Donnery, M.S
Last updated: January 24, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: February 1, 2026

Actual date on which the first participant was enrolled.

This research focuses on understanding whether a non-invasive procedure called Transcranial Magnetic Stimulation (TMS) can influence hormones, specifically Luteinizing Hormone (LH) and Follicle-stimulating hormone (FSH), in healthy women during the luteal phase of their menstrual cycle. The luteal phase is the second half of the menstrual cycle, following ovulation. The study aims to explore if TMS can mimic the natural hormonal signals that stimulate LH secretion, potentially leading to a better understanding of hormonal regulation. During the study, TMS is applied to a specific area of the brain known as the Dorsolateral Prefrontal Cortex. The effect of TMS is then measured by observing changes in LH and FSH levels at six different time points. Blood samples are collected for this purpose. The primary outcome of the study is to evaluate these changes in hormone levels within each participant and compare the results between active TMS and a placebo (sham) stimulation. The study does not mention any specific risks or benefits associated with participation.

Official TitleFeasibility Study Protocol: TMS-Induced LH Response in Healthy Women in the Luteal Phase 
Principal SponsorThe City College of New York
Study ContactKyle Donnery, M.S
Last updated: January 24, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

10 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Basic Science Study

Basic science studies help researchers understand how the body works or how a disease develops. They don't test treatments, but they build the foundation for future therapies.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Female

Biological sex of participants that are eligible to enroll.

From 22 to 40 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

2 inclusion criteria required to participate
Healthy women aged 22-40 years with regular menstrual cycle.

In luteal phase at the time of visit.

16 exclusion criteria prevent from participating
Presence of any known structural brain abnormalities or tumors.

Presence of metal implants/devices in the head or neck.

Has ever had a stroke, seizure, or has a family history of epilepsy.

Head injury with loss of consciousness.

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups

2 intervention groups are designated in this study

50% chance of being blinded to the placebo group

Treatment Groups

Group I

Active Comparator
Participants in this group receive stimulation to the left DLPFC using the NeuroStar system. The stimulation intensity is standardized based on resting motor threshold.

Group II

Sham
Participants receive a sham treatment that mimics the real Transcranial Magnetic Stimulation (TMS) procedure, but does not deliver an effective magnetic field to the brain.

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Site 1

New York, United StatesSee the location
Recruiting soonOne Study Center