Recruiting

Veverimer for Adults with CKD and Metabolic Acidosis

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What is being tested

Veverimer

+ Placebo

Drug
Who is being recruted

Acid-Base Imbalance+1

+ Acidosis

+ Metabolic Diseases

Over 18 Years
+31 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Placebo-ControlledPhase 3
Interventional
Study Start: January 2026
See protocol details

Summary

Principal SponsorRenibus Therapeutics, Inc.
Study ContactAyla Rasmussen
Last updated: March 25, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: January 13, 2026

Actual date on which the first participant was enrolled.

This study focuses on evaluating the effectiveness and safety of a treatment called veverimer in adults diagnosed with moderate-to-severe chronic kidney disease (CKD) who also have metabolic acidosis, a condition where the body produces too much acid. The goal is to understand if veverimer can help manage these conditions better, potentially improving the quality of care for those affected. During this 26-week study, participants will receive veverimer treatment. The study measures the results by observing changes in the serum bicarbonate concentration, a key indicator of acid levels in the body. Additionally, it assesses if veverimer improves physical performance using a test called the Sit-to-Stand 5 times test (STS5), which evaluates lower body strength and balance.

Official TitleA Phase 3, Randomized, Double-Blind Study to Evaluate the Efficacy and Safety of Veverimer in Adults With CKD and Metabolic Acidosis (The REVIVE Study)
NCT07355062
Principal SponsorRenibus Therapeutics, Inc.
Study ContactAyla Rasmussen
Last updated: March 25, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

150 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Acid-Base ImbalanceAcidosisMetabolic DiseasesNutritional and Metabolic Diseases

Criteria

8 inclusion criteria required to participate
CKD with eGFR < 60 mL/min/1.73m²; not expected to need dialysis/ transplant during study.
Willing to maintain stable diet .
Expect to keep oral alkali therapy dose stable.
Women of childbearing potential: negative pregnancy test and agree to abstinence or contraception.
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23 exclusion criteria prevent from participating
History or current diagnosis of clinically significant gastroparesis or a history of bariatric surgery.
History or current diagnosis of bowel obstruction, swallowing disorders, severe gastrointestinal disorders, including inflammatory bowel disease, major gastrointestinal surgery, or known active gastric/duodenal ulcers.
Active Helicobacter pylori infection at screening.
Active, recurrent, or metastatic malignancy at the start of screening.
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Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

50% chance of being blinded to the placebo group

Treatment Groups

Group I

Experimental

Group II

Placebo

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 9 locations

Recruiting

Academic Medical Research Institute

Los Angeles, United StatesOpen Academic Medical Research Institute in Google Maps
Recruiting

Velocity Clinical Research

Edgewater, United States
Recruiting

Belkis Delgado MD PA

Miami Springs, United States
Recruiting

Research by Design

Chicago, United States
Recruiting
9 Study Centers