MIHComparative Evaluation of Computer-Assisted Intraosseous and Infiltration Anesthesia Techniques in Children with Molar-Incisor Hypomineralization
This study aims to compare the stress levels, measured through salivary Chromogranin A levels, in children with Molar-Incisor Hypomineralization undergoing dental treatment using either computer-assisted intraosseous or infiltration anesthesia techniques.
Intraosseous anaesthesia using a computerized system
+ Infiltration anaesthesia using a computerized system
Congenital Abnormalities+14
+ Developmental Defects of Enamel
+ Dental Enamel Hypomineralization
Treatment Study
Summary
Study start date: November 7, 2025
Actual date on which the first participant was enrolled.This research focuses on children with Molar-Incisor Hypomineralization (MIH), a condition that affects the enamel of molars and incisors, making them more prone to cavities. The study aims to find a minimally invasive and effective way to administer anesthesia for these children during dental treatments. It includes children aged 6 to 12 years who have MIH and cavities not reaching the pulp in their upper permanent first molars. The study is important as it addresses the challenge of managing pain in children with MIH, a condition known to respond differently to anesthesia due to enamel changes. The study involves three sessions. In the first session, a detailed medical and dental history is taken, and the degree of MIH and cavities are evaluated. No invasive procedures are performed in this session. In the second and third sessions, two different anesthesia methods are applied to the upper right and left first permanent molars, respectively. The order of anesthesia methods is determined by randomization. During these sessions, the child's pain level, pulse rate, and saliva samples are collected at various stages. The saliva samples are used to measure stress levels. The child's behavior during treatment is also recorded for evaluation. The study's outcome will help in understanding which anesthesia method is more effective and less stressful for children with MIH.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.30 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 6 to 12 Years
Range of ages for which participants are eligible to join.Healthy volunteers allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.2 intervention groups are designated in this study
This study does not include a placebo group
Treatment Groups
Group I
ExperimentalGroup II
Active ComparatorStudy Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location