FAMILYExploration of High-risk Coronary Atherosclerosis in Patients with Family History of CAD

This study, known as the FAMILY Study, focuses on individuals with a family history of coronary artery disease (CAD), a condition where the blood supply to the heart is reduced due to narrowed or blocked arteries. The goal is to understand the prevalence of high-risk atherosclerosis, a buildup of fats, cholesterol and other substances in and on the artery walls, which can lead to cardiovascular events. The study aims to explore whether advanced imaging techniques like cardiac CT (CCT) can help in better understanding the risk and improving prevention strategies, as well as investigating potential links between genetic background and high-risk atherosclerosis. In this study, a group of individuals without symptoms but with a family history of CAD will be enrolled. They will undergo a detailed CCT scan to analyze the state of their arteries. Additionally, a blood sample will be collected for further bio-humoral and genetic investigation. The study will measure the prevalence of high-risk atherosclerosis, evaluate how the CCT scan results compare to standard clinical evaluations, and explore potential links between genetic profiles and high-risk atherosclerosis.