Recruiting

SAMIImproved RUTF Treatment for Acute Malnutrition and Anemia in Children

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Study Aim

This study aims to enhance the treatment for acute malnutrition and anemia in children using an improved formulation of Ready-to-Use Therapeutic Food (RUTF).

What is being tested

Iron absorption from RUTF on Day 0

+ Treatment with RUTF for 80 days

+ Iron absorption from RUTF on Day 20

OtherDietary Supplement
Who is being recruted

Severe Acute Malnutrition+8

+ Iron Deficiencies

+ Anemia

From 12 to 54 Months
See all eligibility criteria
How is the trial designed

Other Study

Interventional
Study Start: December 2025
See protocol details

Summary

Principal SponsorETH Zurich
Study ContactSuzane Nyilima, MSc
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: December 23, 2025

Actual date on which the first participant was enrolled.

This study focuses on improving Ready-to-Use Therapeutic Foods (RUTFs) used for treating malnourished children in Kenya, specifically in Kwale County. The current RUTFs are reported to have limited effectiveness in addressing malnutrition and anemia, possibly due to an excessively high iron content. When children are severely acutely malnourished (SAM), their bodies struggle to absorb iron, potentially leading to severe diarrhea. This study aims to create a safer and more effective RUTF treatment that combats both acute malnutrition and anemia in children. During the study, researchers will compare how well healthy children and those with acute malnutrition absorb iron from RUTFs. They will also track changes in iron absorption in malnourished children throughout their treatment. The study's primary goal is to understand the impact of malnutrition on the body's ability to absorb iron from RUTFs, which could potentially lead to improvements in the formulation of these therapeutic foods.

Official TitleMaximizing the Benefits of Iron in Ready-to-use Therapeutic Foods for Malnourished Children in Kenya
Principal SponsorETH Zurich
Study ContactSuzane Nyilima, MSc
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

68 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Other Study

Some studies explore topics that don't fall into a specific category. These might include innovative research, new technologies, or emerging healthcare areas.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 12 to 54 Months

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Severe Acute MalnutritionIron DeficienciesAnemiaHematologic DiseasesHemic and Lymphatic DiseasesMetabolic DiseasesNutrition DisordersNutritional and Metabolic DiseasesChild Nutrition DisordersIron Metabolism DisordersMalnutrition

Criteria

Inclusion Criteria: malnourished children: * severe acute malnutrition (SAM): WHZ \< -3.0 * moderate acute malnutrition (MAM): WHZ \< -2.0 a * treated as outpatients (no acute medical conditions and a positive appetite test) healthy children: \- healthy: HAZ, WAZ and WHZ = 0 Exclusion Criteria (both groups): * Hemoglobin ≤7 g/dL * Presence of acute medical conditions requiring inpatient management

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
children with moderate or severe acute malnutrition

Group II

Active Comparator
Healthy children

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 2 locations

Recruiting

ETH/Oxford/JKUAT research facility

Msambweni, KenyaOpen ETH/Oxford/JKUAT research facility in Google Maps
Recruiting soon

ETH Zurich, Laboratory of Clinical Biopharmacy, Zurich, 8092

Zurich, Switzerland
Recruiting
2 Study Centers