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Effects of Leg Exercises and Compression Stockings on Prevention of Muscle Cramps in Hemodialysis Patients

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Study Aim

This study aims to investigate how leg exercises and compression stockings can help prevent muscle cramps in individuals undergoing hemodialysis.

What is being tested

legs exercises

+ compression stockings

Device
Who is being recruted

Muscle Cramp+5

+ Muscular Diseases

+ Musculoskeletal Diseases

From 18 to 70 Years
See all eligibility criteria
How is the trial designed

Prevention Study

Interventional
Study Start: December 2025
See protocol details

Summary

Principal SponsorKarbala University
Study Contactzahraa A Kareem, MGSMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: December 25, 2025

Actual date on which the first participant was enrolled.

This study focuses on patients undergoing hemodialysis, a common treatment for end-stage renal disease. A significant issue these patients often face is muscle cramps, which can be severe and painful, affecting their quality of life and even leading some to consider stopping dialysis. The study aims to explore non-pharmacological methods to prevent these cramps, specifically leg exercises and compression stockings. This is important as pharmacological methods can increase the risk of drug toxicity in these patients. The goal is to improve the quality of life for hemodialysis patients and reduce the risk of treatment discontinuation. During dialysis, leg exercises increase blood flow to the muscles, providing necessary energy and improving the clearance of waste products like urea. This also helps move ions such as potassium and phosphate from the cells into the muscle interstitial fluid, improving blood flow and potentially alleviating pain. On the other hand, graduated compression stockings apply a pressure gradient that promotes blood flow towards the heart, reducing the diameter of major veins and increasing the velocity and volume of blood flow. This can effectively reverse elevated venous blood pressure, enhance skeletal muscle pumping, facilitate venous return, and improve lymphatic drainage. The study will evaluate the effectiveness of these methods in preventing muscle cramps.

Official TitleEffect of Legs Exercises and Compression Stockings in the Prevention of Muscle Cramps Among Hemodialysis Patients
Principal SponsorKarbala University
Study Contactzahraa A Kareem, MGSMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

108 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Prevention Study

Prevention studies aim to stop a disease from developing. They often involve people at risk and test things like vaccines, lifestyle changes, or preventive medications.


Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 70 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Muscle CrampMuscular DiseasesMusculoskeletal DiseasesNervous System DiseasesNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and SymptomsNeuromuscular Manifestations

Criteria

Inclusion Criteria: * Those who are at least eighteen years old. * Both genders (male \& female). * Undergoing regular hemodialysis. * Patients who are conscious and cooperative. * Patients experiencing muscle cramps during hemodialysis session. * Patients who would like to participate in part in the study . * Patients with verbally communicated skills. Exclusion Criteria: * Irregular hemodialysis treatment * Presence of femoral catheters * Any lower limb pathology or musculoskeletal impairments * Patients undergoing emergency or first-time hemodialysis * Pilot study participants. * Patients decline to take part in the trial. * Patients who are unable to tolerate the exercises and compression stockings .

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Active Comparator
participants in the Legs Exercises Group were trained to use a mini stationary bike in a supine position for 30 minute from the end of the second hour to the beginning of the third hour of hemodialysis session once per session and the same was repeated for 3 such session . The exercise was performed under the supervision of a trained nurse.

Group II

Active Comparator
Participants in the Compression Stockings Group: apply Compression stockings for 30 minutes from the end of the second hour to the beginning of the third hour of hemodialysis session once per session and the same was repeated for 3 such session .

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.
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