Pegasus 2Lung Perfusion PET/CT for Reduced Radiation Injury in Lung SBRT

This study focuses on improving the way radiation treatment is planned for patients with lung tumors. It aims to reduce the risk of lung damage that can occur as a side effect of stereotactic body radiotherapy (SBRT), a common treatment for lung cancer. A new imaging technique, 68Ga-MAA lung perfusion PET/CT, is being tested to create a more personalized treatment plan by identifying which parts of the lung are most functional and should be protected during radiation. The goal is to minimize lung injury, which can affect up to 20% of patients, by targeting the radiation more precisely. Participants in this study will undergo SBRT guided by this new imaging method to compare its effectiveness against the traditional planning method that uses anatomical lung images. The study will assess whether this functional planning approach reduces the occurrence of significant lung toxicity, known as radiation-induced lung injury, within a year after treatment. The effects will be measured by a medical oncologist who does not know which treatment plan each participant received, ensuring unbiased results. This research could lead to safer and more effective lung cancer treatments by protecting lung function while still effectively treating the tumor.