SAFERPeanut Allergy Biomarkers in Oral Food Challenge for Children and Teens

This study is focused on understanding how children and teenagers, aged 12 months to 17 years, react to peanuts during an oral food challenge. The aim is to identify specific markers in the blood that can predict allergic reactions. This research is important because it could lead to better ways of diagnosing peanut allergies and predicting severe reactions, which can help improve safety and care for young people with potential peanut allergies. The researchers hope to include over 500 participants to ensure a comprehensive study, with special attention to including enough children who do react and those who do not. Participants will first attend a screening visit to ensure they are eligible for the study and to collect initial blood samples. Following this, they will undergo a controlled peanut oral food challenge, which may occur on the same day or within four weeks after the screening. During this challenge, children will be given measured amounts of peanut protein to see at what point, if any, they show allergic symptoms. Clinical assessments, questionnaires, and additional blood samples will be collected throughout the process to monitor reactions and gather data. Once the challenge and a subsequent safety period are completed, the participant's involvement in the study ends.