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PONDERPelvic Peritonectomy for Early Stage Ovarian Tumors

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Study Aim

This study is designed to determine whether pelvic peritonectomy can effectively detect microscopic implants in patients with early-stage ovarian tumors.

What is being tested

systematic surgical approach to wider peritoneal biopsies according with dissection of retroperitoneal spaces, nerve-sparing approach

+ Histopathologic Analysis

ProcedureDiagnostic Test
Who is being recruted

Urogenital Diseases+12

+ Genital Diseases

+ Adnexal Diseases

Over 18 Years
See all eligibility criteria
How is the trial designed

Diagnostic Study

Interventional
Study Start: February 2026
See protocol details

Summary

Principal SponsorOspedale Santa Croce-Carle Cuneo
Study ContactAndrea Puppo, MDMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: February 1, 2026

Actual date on which the first participant was enrolled.

This study is designed to explore a surgical technique for early stage ovarian tumors. Specifically, it examines a method called pelvic peritonectomy, where certain areas of the pelvic lining are carefully removed. This technique aims to enhance the detection of very small cancerous growths that might not be visible otherwise. Identifying these growths is crucial because it could help prevent the cancer from returning in the pelvis. Women with early-stage ovarian cancer may benefit from this study as it seeks to improve surgical outcomes and inform future treatment approaches. Participants in the study will undergo an interventional procedure where surgeons will meticulously remove specific areas of the pelvic lining and examine the tissue for any hidden cancer cells. This process involves a careful dissection to preserve important nerves, aiming to minimize side effects. The study will measure the success of this technique by assessing how often these hidden cancer cells are found in the tissue samples taken during surgery. Understanding these findings can lead to better strategies for preventing the recurrence of ovarian cancer.

Official TitlePelvic peritOnectomy iN Early Stage Ovarian Tumors: a prospEctive Study
Principal SponsorOspedale Santa Croce-Carle Cuneo
Study ContactAndrea Puppo, MDMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

390 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Diagnostic Study

Diagnostic studies focus on improving how we detect or confirm a disease. They test new tools or techniques that could provide faster or more accurate diagnoses.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Female

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Urogenital DiseasesGenital DiseasesAdnexal DiseasesEndocrine System DiseasesEndocrine Gland NeoplasmsFemale Urogenital Diseases and Pregnancy ComplicationsGenital Diseases, FemaleGenital Neoplasms, FemaleGonadal DisordersNeoplasmsNeoplasms by SiteOvarian DiseasesOvarian NeoplasmsUrogenital NeoplasmsFemale Urogenital Diseases

Criteria

Inclusion Criteria: * Age ≥ 18 years * FIGO 2018 stage IA-IB epithelial or non-epithelial ovarian or fallopian tube tumors * Complete preoperative work-up (ultrasound, CT scan, tumor markers) * Laparoscopic, robotic or open surgical approach * Signed informed consent Exclusion Criteria: * Sarcomas, melanomas, mesotheliomas, hematologic malignancies * Advanced ovarian tumors * Fertility-sparing surgery with uterine preservation * Inability to provide informed consent

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

All patients will receive standard pre-, intra-, and postoperative care according to institutional guidelines. The peritonectomy procedure will not alter the choice of surgical access. Pelvic peritonectomy specimens will be analyzed as part of the final pathology report.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Azienda Ospedaliera Santa Croce e Carle Cuneo

Cuneo, ItalyOpen Azienda Ospedaliera Santa Croce e Carle Cuneo in Google Maps
Recruiting soonOne Study Center