Anesthetic Techniques Impact on Oxidative Stress in VATS

This study is examining how different types of anesthesia affect oxidative stress during lung surgery that involves breathing through only one lung at a time. Oxidative stress is a condition that can cause damage to the body and is a concern during surgeries that involve reintroducing air into a previously non-ventilated lung. The study is focused on patients undergoing video-assisted thoracoscopic surgery, a less invasive type of lung surgery, and aims to find out which anesthetic technique—Total Intravenous Anesthesia (TIVA), Combined Intravenous-Volatile Anesthesia (CIVA), or Balanced Anesthesia (BAL)—is the most effective in reducing oxidative stress and preserving oxygen levels. By evaluating these techniques, the research hopes to improve patient safety and outcomes during such surgeries. Participants in the study will be randomly assigned to one of three anesthesia groups: TIVA, CIVA, or BAL. Each group will receive specific combinations of medications to maintain anesthesia, and their effects will be monitored throughout the surgery. Blood samples will be collected at three key moments: before anesthesia starts, before switching back to normal two-lung ventilation, and 30 minutes after resuming two-lung ventilation. These samples will help measure levels of oxidative stress markers like Malondialdehyde, Superoxide Dismutase, and others. The study will also track heart rate, blood pressure, and other vital signs to assess the overall effects of the anesthesia. Results will be analyzed to determine which method best minimizes oxidative stress and improves surgery outcomes.