Intravoxel Incoherent Motion MRI for Lymphovascular Invasion Prediction in Rectal Cancer
This study observes how a specific MRI technique can help predict cancer spread in individuals with rectal cancer to better understand potential recurrence.
Data Collection
Collected from past medical records and data - RetrospectiveDigestive System Diseases+8
+ Digestive System Neoplasms
+ Gastrointestinal Diseases
Cohort
Tracking disease incidence in order to identify risk factors and understand disease progression over time.Summary
Study start date: November 1, 2027
Actual date on which the first participant was enrolled.Rectal cancer is a common type of cancer affecting the digestive system, known for its varied nature among patients. Traditional treatments involve a combination of chemotherapy, radiation, and surgery, which have lowered recurrence rates but haven't prevented cancer from spreading to other parts of the body in a significant number of cases. Accurate predictions of how cancer will behave can help doctors tailor treatments to each patient's needs. Lymphovascular invasion (LVI) is a factor linked to the spread of cancer and poorer outcomes. Identifying LVI before surgery is important as it influences treatment decisions and can lead to better management of the disease, potentially improving survival rates. This study investigates a new imaging technique, called intravoxel incoherent motion (IVIM) MRI, to see if it can more accurately predict the presence of LVI and provide insights into the likely progression of rectal cancer. Participants undergo non-invasive MRI scans, which help to visualize how water moves through the body and blood flows in small vessels. The study measures the effectiveness of this method by tracking the occurrence of cancer recurrence or spread and using various medical tests and scans to confirm findings. The aim is to determine if this technique can offer a reliable way to predict cancer behavior and improve treatment strategies, hopefully leading to better outcomes for patients.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.400 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Cohort
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion Criteria: * (1) patients underwent preoperative abdominal pelvic IVIM-MRI examination; (2) patients underwent surgical resection within 2 weeks after IVIM-MRI examination; (3) complete postoperative pathological data, including LVI status. Exclusion Criteria: * (1) radiotherapy or chemotherapy before surgery; (2) preoperative metastatic disease; (3) poor image quality; (4) incomplete clinical data.
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.Study Objectives
Primary Objectives