CHX+CDOMouthwash with Chlorhexidine and Chlorine Dioxide for Oral Malodor
This study aims to evaluate how mouthwash containing chlorhexidine and chlorine dioxide affects oral malodor by measuring changes in certain compounds in your breath.
CHX 0.01% + CDO 0.05% mouthwash
+ Placebo mouthwash
Halitosis+1
+ Signs and Symptoms
+ Signs and Symptoms, Digestive
Treatment Study
Summary
Study start date: September 5, 2023
Actual date on which the first participant was enrolled.This study aims to help people suffering from bad breath, a condition that can greatly affect one's social interactions and self-esteem. Researchers are testing a special mouthwash that contains chlorhexidine and chlorine dioxide to see if it can effectively reduce bad breath. The study involves 40 participants who experience this issue. Understanding and finding a solution for oral malodor is important as it can improve individuals' quality of life and reduce social embarrassment associated with halitosis. Participants in this trial use the mouthwash twice daily for two weeks, then pause for two weeks before switching to a different treatment. The study is designed to be rigorous, with neither participants nor researchers knowing who is using the active mouthwash and who is using a placebo, which is a fake treatment. Researchers measure the levels of certain sulfur compounds in the breath, which are responsible for bad breath, using a device called OralChroma. They also assess other factors like plaque, gum health, tongue coating, and bacteria in saliva to see if the mouthwash provides additional oral health benefits or risks.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.40 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 18 to 65 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion Criteria: * ≥20 natural teeth * H₂S \>1.5 ng/10ml or CH₃SH \>0.5 ng/10ml * Signed informed consent Exclusion Criteria: * Systemic disease * Smoking * Pregnancy or lactation * Periodontal pockets ≥4 mm * Recent antibiotic use (\<1 month) * Orthodontic appliances or dentures * Allergy to CHX or C
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.2 intervention groups are designated in this study
50% chance of being blinded to the placebo group
Treatment Groups
Group I
ExperimentalGroup II
PlaceboStudy Objectives
Primary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
Odonto-Stomatology Hospital of Ho Chi Minh City
Ho Chi Minh City, VietnamOpen Odonto-Stomatology Hospital of Ho Chi Minh City in Google Maps