Completed

CHX+CDOMouthwash with Chlorhexidine and Chlorine Dioxide for Oral Malodor

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Study Aim

This study aims to evaluate how mouthwash containing chlorhexidine and chlorine dioxide affects oral malodor by measuring changes in certain compounds in your breath.

What is being tested

CHX 0.01% + CDO 0.05% mouthwash

+ Placebo mouthwash

Other
Who is being recruted

Halitosis+1

+ Signs and Symptoms

+ Signs and Symptoms, Digestive

From 18 to 65 Years
See all eligibility criteria
How is the trial designed

Treatment Study

Placebo-Controlled
Interventional
Study Start: September 2023
See protocol details

Summary

Principal SponsorCan Tho University of Medicine and Pharmacy
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: September 5, 2023

Actual date on which the first participant was enrolled.

This study aims to help people suffering from bad breath, a condition that can greatly affect one's social interactions and self-esteem. Researchers are testing a special mouthwash that contains chlorhexidine and chlorine dioxide to see if it can effectively reduce bad breath. The study involves 40 participants who experience this issue. Understanding and finding a solution for oral malodor is important as it can improve individuals' quality of life and reduce social embarrassment associated with halitosis. Participants in this trial use the mouthwash twice daily for two weeks, then pause for two weeks before switching to a different treatment. The study is designed to be rigorous, with neither participants nor researchers knowing who is using the active mouthwash and who is using a placebo, which is a fake treatment. Researchers measure the levels of certain sulfur compounds in the breath, which are responsible for bad breath, using a device called OralChroma. They also assess other factors like plaque, gum health, tongue coating, and bacteria in saliva to see if the mouthwash provides additional oral health benefits or risks.

Official TitleA Randomized Double-Blind Crossover Clinical Trial Evaluating the Efficacy of a Mouthwash Containing Chlorhexidine and Chlorine Dioxide in Patients With Oral Malodor
Principal SponsorCan Tho University of Medicine and Pharmacy
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

40 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 65 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

HalitosisSigns and SymptomsSigns and Symptoms, DigestivePathological Conditions, Signs and Symptoms

Criteria

Inclusion Criteria: * ≥20 natural teeth * H₂S \>1.5 ng/10ml or CH₃SH \>0.5 ng/10ml * Signed informed consent Exclusion Criteria: * Systemic disease * Smoking * Pregnancy or lactation * Periodontal pockets ≥4 mm * Recent antibiotic use (\<1 month) * Orthodontic appliances or dentures * Allergy to CHX or C

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

50% chance of being blinded to the placebo group

Treatment Groups

Group I

Experimental
Participants rinsed with a test mouthwash containing 0.01% chlorhexidine and 0.05% chlorine dioxide. Each participant used 15 mL of the solution twice daily (morning and evening) for 30 seconds over a period of 2 weeks. The mouthwash bottles were identical in appearance to maintain blinding.

Group II

Placebo
Participants rinsed with a placebo mouthwash containing the same excipients, color, and flavoring agents but without chlorhexidine or chlorine dioxide. Each participant used 15 mL of the placebo solution twice daily for 30 seconds over 2 weeks.

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Odonto-Stomatology Hospital of Ho Chi Minh City

Ho Chi Minh City, VietnamOpen Odonto-Stomatology Hospital of Ho Chi Minh City in Google Maps
CompletedOne Study Center