Recruiting

DISCOVERGlycaemic States Impact on ICU Outcomes

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Study Aim

This study aims to observe the impact of chronic high blood sugar levels on short and long-term outcomes in intensive care patients, including mortality and organ injury, and to examine the prevalence of different blood sugar conditions among these patients.

What is being collected

Data Collection

Collected from today forward - Prospective
Who is being recruted

Diabetes Mellitus+6

+ Endocrine System Diseases

+ Metabolic Diseases

Over 18 Years
See all eligibility criteria
How is the trial designed

Cohort

Tracking disease incidence in order to identify risk factors and understand disease progression over time.
Observational
Study Start: May 2024
See protocol details

Summary

Principal SponsorUniversity Medical Center Groningen
Study ContactJill Moser, PhD
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: May 1, 2024

Actual date on which the first participant was enrolled.

This study focuses on understanding how diabetes and prediabetes affect patients in the intensive care unit (ICU). Diabetes is common among ICU patients, and it can lead to serious issues such as infections, heart problems, and even death. However, not all patients with blood sugar issues are identified because the current system mainly checks if they've been prescribed glucose-controlling medications. This means some cases of undiagnosed or poorly controlled diabetes and prediabetes might be missed. The study aims to discover the real number of ICU patients with various blood sugar conditions and how these conditions impact their health in the short and long term. This is crucial for providing better care to these patients during their ICU stay and after discharge. Patients in this study will not receive a new treatment. Instead, the researchers will use blood tests to measure a marker called glycated hemoglobin (HbA1c), which shows average blood sugar levels over the past two to three months. This measurement is used alongside other health indicators to assess the patients' risk of complications and organ damage. The study will look at how chronic high blood sugar affects organ injury, mortality rates in the ICU, and the patients' health a year after their ICU stay. By identifying the prevalence and effects of different blood sugar levels, the study aims to improve the understanding of diabetes management in critically ill patients.

Official TitleIdentifying Diabetes and Impaired Glucose Tolerance in ICU Patients and Assessing Their Impact on Organ Failure and Outcome.
Principal SponsorUniversity Medical Center Groningen
Study ContactJill Moser, PhD
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

4395 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Cohort

These studies follow a group of individuals with common characteristics (such as a condition or birth year) over a specific period to study health outcomes or exposures.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Diabetes MellitusEndocrine System DiseasesMetabolic DiseasesNutritional and Metabolic DiseasesPathologic ProcessesPathological Conditions, Signs and SymptomsCritical IllnessDisease AttributesGlucose Metabolism Disorders

Criteria

Inclusion Criteria: * All adult patients admitted to the ICU Exclusion Criteria: * None

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 2 locations

Recruiting

Frisius MC

Leeuwarden, NetherlandsOpen Frisius MC in Google Maps
Recruiting

University Medical Center Groningen

Groningen, Netherlands
Recruiting
2 Study Centers