TRANSPAutologous Pulp Transplantation for Necrotic Mature Teeth with Periapical Radiolucency

This clinical study is exploring a new way to treat mature teeth that have become necrotic, which means the tooth's nerve tissue is dead, and there is an area of bone loss at the root's tip, known as periapical radiolucency. The research is focused on using a person's own dental pulp tissue, possibly combined with a concentrated growth factor, as a biologic alternative to traditional root canal treatments. This approach could help regenerate tissue and restore the function of these affected teeth. This study is important because it may offer a more natural and potentially more effective option for dental patients with this specific problem. Participants in this study are adults with single-rooted teeth that have been diagnosed with pulp necrosis and periapical issues. They are randomly assigned to one of three treatment groups: one receiving only pulp transplantation, another receiving pulp transplantation plus a growth factor, and the third undergoing a standard root canal. The pulp tissue for transplantation is carefully taken from the patient's own non-damaged wisdom teeth. Throughout the study, the success of the treatments is measured by checking the vitality of the pulp using an electric pulp test and through X-ray images at various follow-up times. This study aims to gather essential evidence on whether these new methods are safe and effective for future dental treatments.