Recruiting

Tirzepatide for Obesity in Adults Without Diabetes

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Study Aim

This study evaluates the effectiveness of Tirzepatide in reducing body weight in adults with obesity who do not have diabetes.

What is being tested

Tirzepatide

+ Standard of Care

DrugOther
Who is being recruted

Body Weight+5

+ Nutrition Disorders

+ Nutritional and Metabolic Diseases

Over 18 Years
+2 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 4
Interventional
Study Start: November 2025
See protocol details

Summary

Principal SponsorEli Lilly and Company
Study ContactTrial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) orMore contacts
Last updated: March 20, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: November 24, 2025

Actual date on which the first participant was enrolled.

The study is designed to evaluate the effectiveness of a medication called tirzepatide in helping people with obesity lose weight and prevent the onset of type 2 diabetes. This study specifically focuses on adults who are obese and have at least one other health condition related to their weight, but who do not currently have diabetes. By testing tirzepatide in a real-world setting, the study aims to see if this treatment can offer a new, effective option for weight management and diabetes prevention in this population. Participants in this study will take tirzepatide once a week. The study will compare the results of those taking tirzepatide with those receiving standard care for obesity. Researchers will primarily look at changes in body weight from the start of the study to see how effective the treatment is. The study will last about 260 weeks, allowing enough time to observe long-term effects and any potential benefits of this treatment approach.

Official TitleA Phase 4 Multicenter, Randomized, Open-Label, Interventional Study With Pragmatic Elements Investigating the Effectiveness of Tirzepatide Once Weekly Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes in a Real-World Setting
NCT07247084
Principal SponsorEli Lilly and Company
Study ContactTrial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) orMore contacts
Last updated: March 20, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

3000 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Body WeightNutrition DisordersNutritional and Metabolic DiseasesObesitySigns and SymptomsPathological Conditions, Signs and SymptomsOvernutritionOverweight

Criteria

2 inclusion criteria required to participate
Have a body mass index >= 30 and <= 34.9 kilogram per square meter (kg/m2)

Have an increased waist to height ratio (defined by > 0.5)

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Participants will receive tirzepatide subcutaneously (SC) + standard of care

Group II

Active Comparator

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 25 locations

Recruiting

P89008 Ashton Medical Group

Ashton-under-Lyne, United KingdomOpen P89008 Ashton Medical Group in Google Maps
Recruiting

P89002 The Brooke Surgery

Hyde SK14, United Kingdom
Recruiting

P86004 Peterloo Medical Centre

Manchester, United Kingdom
Recruiting

P87019 Silverdale Medical Practice

Manchester, United Kingdom
Recruiting
25 Study Centers