Anti-seizure Medication Resistance Predictors in Pediatric Epilepsy
This study observes children with epilepsy to identify clinical, EEG, and neuroimaging factors that predict resistance to anti-seizure medications, helping doctors recognize and manage treatment strategies early.
Data Collection
Collected from today forward - ProspectiveBrain Diseases+5
+ Central Nervous System Diseases
+ Epilepsy
Cohort
Tracking disease incidence in order to identify risk factors and understand disease progression over time.Summary
Study start date: December 29, 2025
Actual date on which the first participant was enrolled.Epilepsy is a common condition in children, where recurrent seizures occur due to abnormal brain activity. While many children can control their seizures with medication, a significant number still experience drug-resistant epilepsy, meaning their seizures do not stop despite trying different medications. This study focuses on understanding why some children do not respond to these medications. By identifying factors that predict resistance to treatment, the study aims to help doctors recognize these cases early and consider alternative treatments, potentially improving children's overall health and quality of life. Participants in this study undergo evaluations to identify signs that might predict resistance to epilepsy medications. These evaluations include clinical assessments, EEG tests that measure brain activity, and imaging studies like MRIs to look at brain structure. The goal is to find patterns that could indicate why some children are more likely to have drug-resistant epilepsy. By understanding these patterns, the study hopes to guide future treatment strategies and provide better care and advice to families dealing with pediatric epilepsy.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.200 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Cohort
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 1 to 18 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion Criteria: * Children aged 1-18 years with a confirmed diagnosis of epilepsy. * Both males and females will be included. Exclusion Criteria: * Children younger than 1 year or older than 18 years. * Patients with acute symptomatic seizures (e.g., febrile seizures, metabolic or infectious causes) or pseudo refractory epilepsy (e .g. syncope or uncorrect ASMs) * Patients controlled on antiseizure medications * Refusal of parents or guardians to participate in the study
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.Study Objectives
Primary Objectives
Secondary Objectives