Recruiting soon

Anti-seizure Medication Resistance Predictors in Pediatric Epilepsy

0 criteria met from your profileSee at a glance how your profile meets each eligibility criteria.
Study Aim

This study observes children with epilepsy to identify clinical, EEG, and neuroimaging factors that predict resistance to anti-seizure medications, helping doctors recognize and manage treatment strategies early.

What is being collected

Data Collection

Collected from today forward - Prospective
Who is being recruted

Brain Diseases+5

+ Central Nervous System Diseases

+ Epilepsy

From 1 to 18 Years
See all eligibility criteria
How is the trial designed

Cohort

Tracking disease incidence in order to identify risk factors and understand disease progression over time.
Observational
Study Start: December 2025
See protocol details

Summary

Principal SponsorAssiut University
Study ContactDalia Abdelrahim Fakhry, Principal Investigator
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: December 29, 2025

Actual date on which the first participant was enrolled.

Epilepsy is a common condition in children, where recurrent seizures occur due to abnormal brain activity. While many children can control their seizures with medication, a significant number still experience drug-resistant epilepsy, meaning their seizures do not stop despite trying different medications. This study focuses on understanding why some children do not respond to these medications. By identifying factors that predict resistance to treatment, the study aims to help doctors recognize these cases early and consider alternative treatments, potentially improving children's overall health and quality of life. Participants in this study undergo evaluations to identify signs that might predict resistance to epilepsy medications. These evaluations include clinical assessments, EEG tests that measure brain activity, and imaging studies like MRIs to look at brain structure. The goal is to find patterns that could indicate why some children are more likely to have drug-resistant epilepsy. By understanding these patterns, the study hopes to guide future treatment strategies and provide better care and advice to families dealing with pediatric epilepsy.

Official TitlePredictors of Anti-seizure Medication Resistance in Pediatric Epilepsy
Principal SponsorAssiut University
Study ContactDalia Abdelrahim Fakhry, Principal Investigator
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

200 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Cohort

These studies follow a group of individuals with common characteristics (such as a condition or birth year) over a specific period to study health outcomes or exposures.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 1 to 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Brain DiseasesCentral Nervous System DiseasesEpilepsyNervous System DiseasesNeurologic ManifestationsSeizuresSigns and SymptomsPathological Conditions, Signs and Symptoms

Criteria

Inclusion Criteria: * Children aged 1-18 years with a confirmed diagnosis of epilepsy. * Both males and females will be included. Exclusion Criteria: * Children younger than 1 year or older than 18 years. * Patients with acute symptomatic seizures (e.g., febrile seizures, metabolic or infectious causes) or pseudo refractory epilepsy (e .g. syncope or uncorrect ASMs) * Patients controlled on antiseizure medications * Refusal of parents or guardians to participate in the study

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.
This study has no location dataSave this study to your profile to know when the location data is available.
Recruiting soonNo study centers