Finerenone's Effect on Retinal Health in Chronic Kidney Disease
This study aims to evaluate how the treatment with Finerenone affects retinal health in people with chronic kidney disease by measuring changes in the thickness of the retinal nerve fiber layer.
Finerenone
Urogenital Diseases+9
+ Chronic Disease
+ Female Urogenital Diseases and Pregnancy Complications
Treatment Study
Summary
Study start date: November 20, 2025
Actual date on which the first participant was enrolled.This study aims to explore the effects of a medication called Finerenone on eye health, specifically in patients who have chronic kidney disease (CKD). People with CKD often experience thinning in parts of the eye, such as the retina and choroid. The research is important because it seeks to understand if Finerenone can help improve or protect these eye structures, potentially leading to better vision outcomes for CKD patients. Improving eye health in these patients could be significant because it addresses a common yet challenging aspect of CKD that affects quality of life. In the study, participants will be divided into two groups, one receiving the Finerenone treatment and the other not receiving any treatment. All participants will undergo eye examinations, which include checking their field of vision and using a technique called optical coherence tomography (OCT) to measure different parts of the eye. These tests are done at the start, and then again after 1, 3, and 6 months to see if there are any improvements. In addition to eye tests, blood and urine samples will be taken to monitor kidney function and other health indicators. The study will assess changes in eye measurements and health parameters over time, providing a comprehensive view of how Finerenone might benefit CKD patients.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.40 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.Over 18 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion Criteria: * Age: above 18 years * Diabetic and non-diabetic non-hemodialysis CKD patients (Stage 2 - Stage 4). Exclusion Criteria: * Patients on hemodialysis (HD). * Serum potassium level \> 5.5 mEq/L * Prior/planned ocular interventions (retinal laser treatment, intravitreal injection or vitrectomy). * Pregnant and lactating women * Malignancy
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.One single intervention group is designated in this study
This study does not include a placebo group
Treatment Groups
Group I
ExperimentalStudy Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location