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Finerenone's Effect on Retinal Health in Chronic Kidney Disease

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Study Aim

This study aims to evaluate how the treatment with Finerenone affects retinal health in people with chronic kidney disease by measuring changes in the thickness of the retinal nerve fiber layer.

What is being tested

Finerenone

Drug
Who is being recruted

Urogenital Diseases+9

+ Chronic Disease

+ Female Urogenital Diseases and Pregnancy Complications

Over 18 Years
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 4
Interventional
Study Start: November 2025
See protocol details

Summary

Principal SponsorAlexandria University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: November 20, 2025

Actual date on which the first participant was enrolled.

This study aims to explore the effects of a medication called Finerenone on eye health, specifically in patients who have chronic kidney disease (CKD). People with CKD often experience thinning in parts of the eye, such as the retina and choroid. The research is important because it seeks to understand if Finerenone can help improve or protect these eye structures, potentially leading to better vision outcomes for CKD patients. Improving eye health in these patients could be significant because it addresses a common yet challenging aspect of CKD that affects quality of life. In the study, participants will be divided into two groups, one receiving the Finerenone treatment and the other not receiving any treatment. All participants will undergo eye examinations, which include checking their field of vision and using a technique called optical coherence tomography (OCT) to measure different parts of the eye. These tests are done at the start, and then again after 1, 3, and 6 months to see if there are any improvements. In addition to eye tests, blood and urine samples will be taken to monitor kidney function and other health indicators. The study will assess changes in eye measurements and health parameters over time, providing a comprehensive view of how Finerenone might benefit CKD patients.

Official TitleInvestigating the Impact of Finerenone on Retinal Vascular Dysfunction in Patients With Chronic Kidney Disease
Principal SponsorAlexandria University
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

40 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Urogenital DiseasesChronic DiseaseFemale Urogenital Diseases and Pregnancy ComplicationsKidney DiseasesPathologic ProcessesPathological Conditions, Signs and SymptomsUrologic DiseasesDisease AttributesRenal Insufficiency, ChronicRenal InsufficiencyFemale Urogenital DiseasesMale Urogenital Diseases

Criteria

Inclusion Criteria: * Age: above 18 years * Diabetic and non-diabetic non-hemodialysis CKD patients (Stage 2 - Stage 4). Exclusion Criteria: * Patients on hemodialysis (HD). * Serum potassium level \> 5.5 mEq/L * Prior/planned ocular interventions (retinal laser treatment, intravitreal injection or vitrectomy). * Pregnant and lactating women * Malignancy

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Treatment arm: will receive oral Finerenone in addition to standard treatment. Initial dose of finerenone will be determined according to eGFR: eGFR\>= 60 mL/min: 20 mg once daily. eGFR\>25 mL/min, \<60 mL/min: 10 mg once daily eGFR\<15 mL/min: use is contraindicated Maintenance dose will be determined by the serum potassium level measured 4 weeks after initiation of therapy or dose adjustment according to CKD progression

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Alexandria University

Alexandria, EgyptOpen Alexandria University in Google Maps
Recruiting soonOne Study Center