ICAROHemoadsorption Cartridges for Antibiotics Removal in ICU Patients

This study focuses on understanding how certain antibiotics behave in the body when patients in an Intensive Care Unit (ICU) are treated for severe infections like septic shock. The study specifically looks at the combination of antibiotics such as meropenem with either linezolid or daptomycin. These patients are also receiving a treatment called Continuous Renal Replacement Therapy (CRRT), which helps filter waste from the blood when the kidneys are not working well. The study aims to see how a device called the HA380 cartridge affects the levels of these antibiotics in the blood. This is important because understanding how these treatments interact could help improve the effectiveness and safety of treating severe infections in ICU patients. During the study, participants will undergo CRRT using a special machine that includes the HA380 cartridge to filter out inflammatory substances from their blood. Blood samples will be taken at different times to measure how much of the drug is present before and after it passes through the HA380 filter. The samples are carefully processed and stored to ensure accurate measurement using advanced techniques. This study is observational, meaning it looks at what happens naturally without intervening. The researchers will analyze the percentage change in drug concentration to understand the cartridge's impact. This can help determine whether the HA380 cartridge affects the effectiveness of the antibiotics, providing valuable insights into optimizing care for critically ill patients.