Recruiting

Apomorphine Infusion Experiences in Parkinson's Disease

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What is being collected

Data Collection

Collected from today forward - Prospective
Who is being recruted

Synucleinopathies+6

+ Basal Ganglia Diseases

+ Brain Diseases

Over 18 Years
See all eligibility criteria
How is the trial designed

Cohort

Tracking disease incidence in order to identify risk factors and understand disease progression over time.
Observational
Study Start: March 2025
See protocol details

Summary

Principal SponsorSupernus Pharmaceuticals, Inc.
Study ContactMindy Grall, PhD ANP-BCMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: March 31, 2025

Actual date on which the first participant was enrolled.

This study is focused on understanding the real-world experiences of patients in the United States using a treatment called ONAPGO, which is a continuous subcutaneous apomorphine infusion, specifically designed for individuals with Parkinson's Disease. Parkinson's Disease is a condition that affects movement and can cause tremors, stiffness, and other symptoms. The study aims to gather insights into how patients manage their symptoms using ONAPGO in everyday life. This information is crucial because it helps healthcare providers better understand the practical aspects of using this treatment and can lead to improved care strategies for those living with Parkinson's Disease. Participants in the study go through several stages, starting with an Enrollment Day when they first receive their prescription for ONAPGO. Before starting the infusion, there is a Baseline Period where patients receive in-home education from a Clinical Nurse Navigator on how to use ONAPGO properly. The study involves different phases, including starting the dose, adjusting it as needed, and maintaining the treatment. Throughout the study, participants receive regular care visits from their nurse to ensure proper management of the treatment. At the end of the study, or if they decide to stop the treatment, participants have a final visit to review their experiences. The study does not involve any interventions beyond standard care, and it focuses on observing how the treatment fits into the daily lives of those with Parkinson's Disease.

Official TitleReal-World Patient Experiences Using Continuous Subcutaneous Apomorphine Infusion (ONAPGOTM) in the United States: A Prospective, Phase 4, Multicenter, Observational Study in Parkinson's Disease
Principal SponsorSupernus Pharmaceuticals, Inc.
Study ContactMindy Grall, PhD ANP-BCMore contacts
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

120 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Cohort

These studies follow a group of individuals with common characteristics (such as a condition or birth year) over a specific period to study health outcomes or exposures.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

SynucleinopathiesBasal Ganglia DiseasesBrain DiseasesCentral Nervous System DiseasesMovement DisordersNervous System DiseasesParkinson DiseaseNeurodegenerative DiseasesParkinsonian Disorders

Criteria

Inclusion Criteria: Participant has received a prescription for ONAPGO™ according to the standard of care. Participant has opted into receiving support services from the Clinical Nurse Navigator (CNN), a registered nurse specially trained to work with persons with Parkinson's disease, as noted on the Prescription Enrollment Form. The HCP/Investigator determines the participant is an appropriate study participant. Participant is able and willing to provide informed consent (or informed assent form \[IAF\], as applicable) and signs the consent form on the Enrollment Day. Exclusion Criteria: Did not receive a prescription for ONAPGO™. Prescribed ONAPGO™, but the HCP/Investigator determines the participant should not participate in this observational study. Concomitant use of ONAPGO™ with 5-HT3 antagonists, including antiemetics (e.g., ondansetron, granisetron, dolasetron, palonosetron) or alosetron. Known hypersensitivity to apomorphine or to excipients of ONAPGO™, including sulfite (e.g., sodium metabisulfite).

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 5 locations

Recruiting

Parkinson's Disease and Movement Disorders Center - Orange County (South)

Aliso Viejo, United StatesOpen Parkinson's Disease and Movement Disorders Center - Orange County (South) in Google Maps
Recruiting

Parkinson's Disease and Movement Disorders Center - Orange County (North)

Irvine, United States
Recruiting

Parkinson's Research Centers of America - Palo Alto

Palo Alto, United States
Recruiting

Parkinson's Disease & Movement Disorders Center of Boca Raton

Boca Raton, United States
Recruiting
5 Study Centers