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Magnetocardiography Study for Amyloidosis Disease Detection and Treatment Monitoring

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Study Aim

This study observes how magnetocardiography can help detect and monitor amyloidosis disease, by comparing its effectiveness to electrocardiogram and measuring areas under the curve.

What is being collected

Data Collection

Collected from today forward - Prospective
Who is being recruted

Amyloidosis+1

+ Metabolic Diseases

+ Nutritional and Metabolic Diseases

Over 18 Years
See all eligibility criteria
How is the trial designed

Cohort

Tracking disease incidence in order to identify risk factors and understand disease progression over time.
Observational
Study Start: December 2025
See protocol details

Summary

Principal SponsorMayo Clinic
Study ContactAndy Dang
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: December 3, 2025

Actual date on which the first participant was enrolled.

This study focuses on using a technique called magnetocardiography (MCG) to help diagnose and track the progression of amyloidosis, a condition where abnormal proteins build up in organs and tissues. The goal is to see how well MCG works compared to other methods like the electrocardiogram (ECG), which is commonly used. By finding better ways to detect and monitor this disease, the study hopes to improve the management and care of those affected by amyloidosis. Participants in this study will undergo magnetocardiography, a non-invasive procedure that records the magnetic signals of the heart. The results from these tests are compared to those from traditional ECGs to determine the accuracy and usefulness of MCG in identifying changes related to amyloidosis. This could potentially offer a new, more effective way of tracking the disease over time, ensuring patients receive timely and appropriate treatment adjustments.

Official TitleA Prospective Study of Magnetocardiography for Disease Detection and Monitoring Treatment Outcomes in Amyloidosis
NCT07218705
Principal SponsorMayo Clinic
Study ContactAndy Dang
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

500 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Cohort

These studies follow a group of individuals with common characteristics (such as a condition or birth year) over a specific period to study health outcomes or exposures.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

AmyloidosisMetabolic DiseasesNutritional and Metabolic DiseasesProteostasis Deficiencies

Criteria

Inclusion Criteria 1. Age ≥ 18 years on the date of consent 2. Ability for participant to comply with study requirements 3. Written informed consent Exclusion Criteria 1. Pregnant or breastfeeding 2. Having an active atrial fibrillation episode as seen on most current 12-lead ECG 3. Active thoracic metal implants (including pacemaker, insertable cardiac monitor, or internal defibrillator). 4. External electrical pads or devices (e.g. Pacer pads, ECG electrodes, heart rate patch), that must remain on patient's chest during MCG scan 5. Inability to lie down in a supine/inclined position and stay still on the examination bed 6. Clinical conditions that in the opinion of the Investigator would compromise the safety of the patient or ability to complete the protocol

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

Mayo Clinic in Rochester

Rochester, United StatesOpen Mayo Clinic in Rochester in Google Maps
Recruiting
One Study Center