Completed

Tranexamic Acid for Hemoptysis: Nebulization vs IV

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Study Aim

This study aims to evaluate if nebulized tranexamic acid is as effective as intravenous administration in treating adults experiencing hemoptysis.

What is being tested

Tranexamic Acid (TXA)

Drug
Who is being recruted

Hemoptysis+5

+ Hemorrhage

+ Lung Diseases

From 12 to 80 Years
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 2 & 3
Interventional
Study Start: August 2025
See protocol details

Summary

Principal SponsorUniversity of Health Sciences Lahore
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: August 1, 2025

Actual date on which the first participant was enrolled.

This study is exploring the best way to give tranexamic acid, a medication used to control bleeding, to people experiencing hemoptysis, which is coughing up blood. The study focuses on two methods of delivering the medication: through a nebulizer, which turns the medicine into a mist to be inhaled, and through an intravenous (IV) route, which is delivered directly into the bloodstream. The goal is to determine which method is more effective in stopping the bleeding quickly and preventing it from coming back. This research is important because finding the most efficient way to manage hemoptysis can improve patient outcomes and treatment experiences. Participants in the study will be randomly assigned to one of two groups. One group will receive tranexamic acid through a nebulizer, while the other group will receive it via an IV. The study will track how long it takes for the bleeding to stop completely after each treatment and how soon it might return. Another important measure is the reduction in the amount of blood found in the sputum, or the mucus coughed up from the lungs, after each form of treatment. By comparing these outcomes, researchers aim to identify any potential benefits or risks associated with each delivery method.

Official TitleTranexamic Acid : Nebulization vs IV Route for Hemoptysis
NCT07212452
Principal SponsorUniversity of Health Sciences Lahore
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

172 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 12 to 80 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

HemoptysisHemorrhageLung DiseasesPathologic ProcessesRespiratory Tract DiseasesSigns and SymptomsSigns and Symptoms, RespiratoryPathological Conditions, Signs and Symptoms

Criteria

Inclusion Criteria: 1. Patients with mild to moderate hemoptysis \< 600ml/ 24 hours of age 12 to 80 years and both genders. 2. Patients with hemoptysis due to infective pathology. 3. Patients with hemoptysis due to malignant pathology. Exclusion Criteria: 1. Patients on antiplatelet therapy or aspirin 2. Hemoptysis after penetrating lung injury e.g. firearm injury 3. Patients with history of asthma

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Active Comparator
Tranexamic acid has been used conventionally for hemoptysis via IV route

Group II

Experimental
Tranexamic acid when given through nebulization can be more effective than IV route in controlling hemoptysis

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Services Hospital Lahore

Lahore, PakistanOpen Services Hospital Lahore in Google Maps
CompletedOne Study Center