Tranexamic Acid for Hemoptysis: Nebulization vs IV
This study aims to evaluate if nebulized tranexamic acid is as effective as intravenous administration in treating adults experiencing hemoptysis.
Tranexamic Acid (TXA)
Hemoptysis+5
+ Hemorrhage
+ Lung Diseases
Treatment Study
Summary
Study start date: August 1, 2025
Actual date on which the first participant was enrolled.This study is exploring the best way to give tranexamic acid, a medication used to control bleeding, to people experiencing hemoptysis, which is coughing up blood. The study focuses on two methods of delivering the medication: through a nebulizer, which turns the medicine into a mist to be inhaled, and through an intravenous (IV) route, which is delivered directly into the bloodstream. The goal is to determine which method is more effective in stopping the bleeding quickly and preventing it from coming back. This research is important because finding the most efficient way to manage hemoptysis can improve patient outcomes and treatment experiences. Participants in the study will be randomly assigned to one of two groups. One group will receive tranexamic acid through a nebulizer, while the other group will receive it via an IV. The study will track how long it takes for the bleeding to stop completely after each treatment and how soon it might return. Another important measure is the reduction in the amount of blood found in the sputum, or the mucus coughed up from the lungs, after each form of treatment. By comparing these outcomes, researchers aim to identify any potential benefits or risks associated with each delivery method.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.172 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 12 to 80 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion Criteria: 1. Patients with mild to moderate hemoptysis \< 600ml/ 24 hours of age 12 to 80 years and both genders. 2. Patients with hemoptysis due to infective pathology. 3. Patients with hemoptysis due to malignant pathology. Exclusion Criteria: 1. Patients on antiplatelet therapy or aspirin 2. Hemoptysis after penetrating lung injury e.g. firearm injury 3. Patients with history of asthma
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.2 intervention groups are designated in this study
This study does not include a placebo group
Treatment Groups
Group I
Active ComparatorGroup II
ExperimentalStudy Objectives
Primary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location