Combined Subcision with CO₂ Laser or PRP for Atrophic Post-acne Scars
subcision
+ subcision+fractional co2 laser
+ subcision+PRP
Treatment Study
Summary
Study start date: November 1, 2025
Actual date on which the first participant was enrolled.The study aims to find the most effective treatment for atrophic scars left by acne. Atrophic scars are those that create indentations in the skin. The study compares three methods: subcision alone, subcision combined with platelet-rich plasma (PRP), and subcision combined with fractional CO₂ laser. The target group is individuals with atrophic post-acne scars, and the study takes place at Assiut University Hospital in Egypt. Understanding which treatment works best could significantly improve the appearance of acne scars, providing better options for those seeking cosmetic improvements. Participants will undergo a procedure called subcision, where a needle is used to release tight bands under the skin that cause the scar. This treatment is done on both sides of the face. In group I, PRP is injected on one side, while saline is injected on the other. In group II, a fractional CO₂ laser treats one side, with the other side receiving saline. Each patient receives three treatment sessions, spaced one month apart. Results are measured using scar grading systems and photography, ensuring a comprehensive evaluation. After treatments, participants are advised to avoid sun exposure and use sunscreen to protect their skin. Any discomfort is managed with cold compresses and pain relievers like paracetamol.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.42 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.Over 18 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Criteria
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.3 intervention groups are designated in this study
This study does not include a placebo group
Treatment Groups
Group I
Active ComparatorGroup II
ExperimentalGroup III
ExperimentalStudy Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
Assiut University Hospitals, Dermatology Department
Asyut, EgyptOpen Assiut University Hospitals, Dermatology Department in Google Maps