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Combined Subcision with CO₂ Laser or PRP for Atrophic Post-acne Scars

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What is being tested

subcision

+ subcision+fractional co2 laser

+ subcision+PRP

ProcedureBiological
Who is being recruted

Over 18 Years
+9 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: November 2025
See protocol details

Summary

Principal SponsorAssiut University
Study ContactYasmeen Gamal Abdel Halim
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: November 1, 2025

Actual date on which the first participant was enrolled.

The study aims to find the most effective treatment for atrophic scars left by acne. Atrophic scars are those that create indentations in the skin. The study compares three methods: subcision alone, subcision combined with platelet-rich plasma (PRP), and subcision combined with fractional CO₂ laser. The target group is individuals with atrophic post-acne scars, and the study takes place at Assiut University Hospital in Egypt. Understanding which treatment works best could significantly improve the appearance of acne scars, providing better options for those seeking cosmetic improvements. Participants will undergo a procedure called subcision, where a needle is used to release tight bands under the skin that cause the scar. This treatment is done on both sides of the face. In group I, PRP is injected on one side, while saline is injected on the other. In group II, a fractional CO₂ laser treats one side, with the other side receiving saline. Each patient receives three treatment sessions, spaced one month apart. Results are measured using scar grading systems and photography, ensuring a comprehensive evaluation. After treatments, participants are advised to avoid sun exposure and use sunscreen to protect their skin. Any discomfort is managed with cold compresses and pain relievers like paracetamol.

Official TitleA Combined Subcision Approach With Either Fractional CO₂ Laser or Platelet-rich Plasma Versus Subcision Alone in the Treatment of Atrophic Post-acne Scars
NCT07199608
Principal SponsorAssiut University
Study ContactYasmeen Gamal Abdel Halim
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

42 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

1 inclusion criteria required to participate
Adult patients of both sexes with mild to severe atrophic post-acne scars.

8 exclusion criteria prevent from participating
Age < 18 years

Pregnant or lactating women

Active inflammatory acne or infection in treatment area

Premalignant or malignant lesions

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

3 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Active Comparator

Group II

Experimental

Group III

Experimental

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Assiut University Hospitals, Dermatology Department

Asyut, EgyptOpen Assiut University Hospitals, Dermatology Department in Google Maps
Recruiting soonOne Study Center