Completed

Cysteine-rich Whey Protein for Post COVID-19 Cognitive Impairment

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What is being tested

Intervention with Consolidated Cysteine (Immunocal) 20 g per day

+ Cognitive rehabilitation workshops

OtherBehavioral
Who is being recruted

COVID-19+19

+ Behavior

+ Mental Disorders

From 18 to 70 Years
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: July 2024
See protocol details

Summary

Principal SponsorUniversidad Libre seccional Cali
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: July 1, 2024

Actual date on which the first participant was enrolled.

This study focuses on finding ways to help people who have recovered from COVID-19 but are now facing issues with memory and thinking, known as cognitive impairment. The trial takes place in Cali, Colombia, and involves adults who have mild to moderate difficulties with cognition after COVID-19 but did not previously use the supplement Immunocal. By testing the effects of a cysteine-rich whey protein isolate called Immunocal, along with a structured neuropsychological rehabilitation program, the research aims to improve cognitive functioning in these individuals. This study is important because it could offer new therapies to help individuals regain their cognitive health after COVID-19. Participants in this study are divided into three groups: one receiving Immunocal supplementation, another undergoing neuropsychological rehabilitation, and a control group receiving no treatment. Immunocal is taken daily for 12 weeks by mixing and consuming the supplement. The effectiveness of these interventions is measured through cognitive tests that evaluate attention, memory, and other mental functions, as well as a physical test assessing lower body strength and endurance. These assessments help determine how well the interventions work in improving cognitive and physical health. Participants' symptoms and overall health are also monitored by doctors throughout the study to ensure safety and gather comprehensive health data.

Official TitleUse of a Cysteine-rich Whey Protein Isolate (Immunocal®) in Post COVID-19 Cognitive Impairment
NCT07184398
Principal SponsorUniversidad Libre seccional Cali
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

120 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 70 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

COVID-19BehaviorMental DisordersBehavioral SymptomsCognition DisordersCoronaviridae InfectionsFatigueMental FatigueInfectionsLung DiseasesPneumoniaPneumonia, ViralRespiratory Tract DiseasesRespiratory Tract InfectionsRNA Virus InfectionsSigns and SymptomsPathological Conditions, Signs and SymptomsVirus DiseasesCoronavirus InfectionsNeurocognitive DisordersNidovirales InfectionsCognitive Dysfunction

Criteria

Inclusion: * Adults ≥18 years with confirmed prior COVID-19 * with persistent cognitive symptoms * able to complete testing * and willing to consent. Exclusion: * Pre-existing dementia or major psychiatric illness * whey protein allergy - participation in another cognitive trial * severe hepatic/renal/metabolic disease, pregnancy * or any condition interfering with participation.

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
CRWPI Immunocal® (Immunotec™) was administered at a dose of 20 grams (2 sachets once daily) for 12 consecutive weeks. The research team delivered Immunocal directly to the subjects and instructed them on how to mix and self-administer it.

Group II

Active Comparator
Participants will undergo a structured neuropsychological rehabilitation program targeting memory, attention, and executive function deficits associated with post-COVID-19 cognitive impairment. Standardized cognitive exercises and behavioral strategies will be applied over the intervention period.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Doctor's office

Cali, ColombiaOpen Doctor's office in Google Maps
CompletedOne Study Center
Cysteine-rich Whey Protein for Post COVID-19 Cognitive Impairment | PatLynk