PARAISOIntravenous Prasinezumab for Early-Stage Parkinson's Disease
Prasinezumab
+ Placebo
Synucleinopathies+6
+ Basal Ganglia Diseases
+ Brain Diseases
Treatment Study
Summary
Study start date: November 24, 2025
Actual date on which the first participant was enrolled.This clinical trial focuses on understanding how effective and safe a treatment called prasinezumab is for people who have early-stage Parkinson's disease. Parkinson's disease is a condition that affects movement and often starts with mild symptoms like a slight tremor. The study targets those who are already taking a stable dose of a common Parkinson's medication called levodopa. The goal is to see if prasinezumab can improve their symptoms or slow the progression of the disease. This research is important because finding better treatments can significantly enhance the quality of life for those living with Parkinson's. Participants in this study will receive prasinezumab through an intravenous (IV) infusion, meaning the medicine will be given directly into a vein. Some participants will receive a placebo, which is a substance with no active drug, to compare the effects. The study will monitor how prasinezumab affects the body and its safety for patients. Researchers will evaluate whether the treatment helps with Parkinson's symptoms and assess its overall safety. By comparing prasinezumab to a placebo, the study aims to provide clear insights into its potential benefits and any risks involved.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.900 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Treatment Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 50 to 85 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.2 intervention groups are designated in this study
This study does not include a placebo group
Treatment Groups
Group I
ExperimentalGroup II
ExperimentalStudy Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 38 locations
Neurology Center of North Orange County
Fullerton, United StatesOpen Neurology Center of North Orange County in Google MapsKeck School of Medicine of USC
Los Angeles, United StatesProfound Research LLC at The Neurology Center of Southern California
Pasadena, United StatesUCSF Weill Institute for Neurosciences
San Francisco, United States