ABPCardiac Anodal Biphasic Pacing in Patients with Non-Ischemic Cardiomyopathy

This clinical study focuses on a special type of heart pacing called Anodal Biphasic Pacing (ABP). It is designed to help people with normal heart structures as well as those who have a heart condition known as non-ischemic cardiomyopathy. The participants are individuals who are either getting a new heart device implanted or having an existing one replaced. The goal is to see if ABP can provide better blood flow benefits compared to the traditional method called cathodal pacing. Researchers aim to determine which patients benefit the most from ABP and to ensure it does not have negative effects, especially on those who do not respond to traditional pacing methods. This study could lead to better heart care by optimizing how electronic devices support the heart's function. Participants in this study will undergo procedures at Boston Medical Center, where they will receive or replace a cardiac implantable electronic device (CIED). They will be grouped based on their heart's ability to pump blood, known as the ejection fraction. The study will measure how well ABP improves heart function compared to cathodal pacing, focusing on finding the best settings for ABP. Additionally, safety is a key concern, so the study will look for any unusual heart rhythms and ensure the devices and procedures are safe. The research does not mention specific risks or benefits, but the primary focus is on improving the effectiveness and safety of heart devices for patients.