Completed

REMS vs NEWS2 for Sepsis Prognostication in Emergency Department

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What is being collected

Data Collection

Collected from today forward - Prospective
Who is being recruted

Infections+3

+ Inflammation

+ Pathologic Processes

Over 18 Years
+6 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Other

Utilizing specific methods not covered by standard models in order to address unique research questions.
Observational
Study Start: January 2023
See protocol details

Summary

Principal SponsorJubilee Mission Medical College and Research Institute
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: January 1, 2023

Actual date on which the first participant was enrolled.

This study is designed to evaluate how well two different scoring systems, REMS (Rapid Emergency Medicine Score) and NEWS2 (National Early Warning Score 2), can predict the health outcomes of patients who come to the emergency department with a suspected case of sepsis. Sepsis is a serious medical condition that can lead to severe complications or even death, so being able to predict which patients might experience worse outcomes is very important. While NEWS2 is typically used to monitor patients in the hospital to catch early signs of deterioration, REMS is generally used to predict the risk of mortality in non-surgical patients. Recent research suggests REMS might be even better at predicting outcomes for sepsis patients than other similar scoring systems, making this comparison particularly valuable. In this observational study, researchers will look at patients who arrive at the emergency department with potential sepsis. They will record scores from both the REMS and NEWS2 systems for these patients, without administering any new treatments. Over time, the researchers will track the patients' health outcomes, such as recovery or complications, to see which scoring system more accurately predicts these outcomes. This study does not involve any direct interventions, so participants will not experience any additional risks or benefits beyond the standard care they would normally receive. The main goal is to find out which score provides better information for doctors to improve patient care in the future.

Official TitleProspective Observational Study to Determine the Utility of REMS in Comparison to NEWS2 for Predicting Morbidity and Mortality Among Patients Presenting to the ED Suspicion of Sepsis
NCT07171918
Principal SponsorJubilee Mission Medical College and Research Institute
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

130 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Other

Some studies use unique or mixed approaches that don't fit standard categories. These may include innovative observational methods or studies tailored to specific research questions.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

InfectionsInflammationPathologic ProcessesPathological Conditions, Signs and SymptomsSystemic Inflammatory Response SyndromeSepsis

Criteria

4 inclusion criteria required to participate
All patients presenting to ED of Tertiary Care Hospital in Thrissur.

Patients age >/=18 years

Patients who give informed consent for participation in the study.

Suspicion of sepsis at the time of presentation to ED as per SSC Guidelines 2021

2 exclusion criteria prevent from participating
All patients with an alternate diagnosis other than sepsis at the time of discharge.

Patients referred from other hospitals with diagnosis of sepsis, after initiation of treatment

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Department of Emergency Medicine, Jubilee Mission Medical College and Research Institute

Thrissur, IndiaOpen Department of Emergency Medicine, Jubilee Mission Medical College and Research Institute in Google Maps
CompletedOne Study Center