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Zynex NMES for Post-Operative ACL Rehabilitation

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What is being tested

Zynex NexWave Electrotherapy Device

Device
Who is being recruted

Anterior Cruciate Ligament Injuries+10

+ Asthenia

+ Atrophy

From 15 to 50 Years
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: November 2025
See protocol details

Summary

Principal SponsorUniversity of Kansas Medical Center
Study ContactClinical Research Coordinator/Supervisor - Orthopedic Surgery
Last updated: December 11, 2025
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Study start date: November 1, 2025

Actual date on which the first participant was enrolled.

This study explores the benefits of using Zynex Neuromuscular Electrical Stimulation (NMES) alongside regular rehabilitation for patients recovering from anterior cruciate ligament reconstruction (ACLR) surgery. The goal is to see if NMES can help improve knee movement, muscle strength, and walking abilities more effectively than standard rehabilitation alone. By understanding these effects, the study aims to offer better recovery options for people undergoing ACLR, potentially leading to quicker and more balanced recovery. Participants in the study will follow a typical ACLR rehabilitation program, but some will also use the NMES device. This device is applied to the muscles and sends electrical impulses to stimulate them, which may enhance muscle strength and movement. The study will compare muscle strength and movement symmetry before and after surgery in those using NMES and those who are not, to see if the NMES group shows better outcomes. This approach will help determine if adding NMES to standard rehab truly offers additional benefits.

Official TitleEffects on Patient Outcomes With Post-Operative Use of Zynex Neuromuscular Electrical Stimulation (NMES): Zynex-25 
NCT07171346
Principal SponsorUniversity of Kansas Medical Center
Study ContactClinical Research Coordinator/Supervisor - Orthopedic Surgery
Last updated: December 11, 2025
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

25 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 15 to 50 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Anterior Cruciate Ligament InjuriesAstheniaAtrophyKnee InjuriesLeg InjuriesMuscular AtrophyNervous System DiseasesNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and SymptomsWounds and InjuriesPathological Conditions, AnatomicalNeuromuscular Manifestations

Criteria

Inclusion Criteria: * ACLR surgical patients at KUMC sports medicine * 15 to 50 years old * BMI between 18 - 30 kg/m2 * No limitations impacting physical function within the last 6 months (not including the ACL injury) Exclusion Criteria: * Previous lower limb or spine injury involving surgical treatment * Prior spine surgery * Lower limb injury (other than ACL) preventing participation in physical activity for over two weeks in the past 6 months * Non english speaking * Vulnerable population, prisoner, or ward of the state

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
All participants will use the NMES device in addition to standard rehab protocol

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

University of Kansas Medical Center

Kansas City, United StatesSee the location
Recruiting soonOne Study Center