Recruiting

RSV Vaccine Uptake in Latino Older Adults

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What is being tested

Motivate Aim: CHW text message reminders and counseling

+ Motivate Aim: CHW text message reminders only
+ Activate Aim: CHW text message reminders and counseling
Behavioral
Who is being recruted

Over 18 Years
See all eligibility criteria
How is the trial designed

Other Study

Interventional
Study Start: September 2025
See protocol details

Summary

Principal SponsorUniversity of California, San Francisco
Study ContactRSV Uptake Study Coordinator
Last updated: December 11, 2025
Sourced from a government-validated database.Claim as a partner
Study start date: September 10, 2025Actual date on which the first participant was enrolled.

The study focuses on increasing the uptake of the RSV (respiratory syncytial virus) vaccine among Latino older adults. This is achieved by using a community-based approach that includes counseling by community health workers and sending text message reminders. The study is crucial as it aims to address the low rates of RSV vaccination in this community, which can help prevent serious respiratory illnesses among older adults. By improving vaccination rates, the study hopes to enhance overall health and reduce the burden of RSV-related diseases in this population. Participants in the study are divided into groups to receive different interventions. Some will receive counseling from community health workers and text messages to encourage them to get the RSV vaccine, while others will only receive text messages. In another part of the study, younger Latino adults are encouraged to discuss RSV vaccination with older people in their social circles. The success of the interventions is measured by the number of older adults who get vaccinated and the number of discussions about the vaccine among social networks. The study uses community-based research methods to ensure the interventions are relevant and effective for the participants.

Official TitleMotivate Vaccinate Activate: An Effectiveness-Implementation Trial to Assess the Impact of a Multi-Component Community-Based Intervention to Increase RSV Vaccine Uptake Among Latino Older Adults 
NCT07171164
Principal SponsorUniversity of California, San Francisco
Study ContactRSV Uptake Study Coordinator
Last updated: December 11, 2025
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details
750 patients to be enrolledTotal number of participants that the clinical trial aims to recruit.
Other Study
Some studies explore topics that don't fall into a specific category. These might include innovative research, new technologies, or emerging healthcare areas.

How participants are assigned to different groups/arms
In this clinical study, participants are placed into groups randomly, like flipping a coin. This ensures that the study is fair and unbiased, making the results more reliable. By assigning participants by chance, researchers can better compare treatments without external influences.

Other Ways to Assign Participants
Non-randomized allocation: Participants are assigned based on specific factors, such as their medical condition or a doctor's decision.
None (Single-arm trial): If the study has only one group, all participants receive the same treatment, and no allocation is needed.

How treatments are given to participants
Participants are divided into different groups, each receiving a specific treatment at the same time. This helps researchers compare how well different treatments work against each other.

Other Ways to Assign Treatments
Single-group assignment: Everyone gets the same treatment.
Cross-over assignment: Participants switch between treatments during the study.
Factorial assignment: Participants receive different combinations of treatments.
Sequential assignment: Participants receive treatments one after another in a specific order, possibly based on individual responses.
Other assignment: Treatment assignment does not follow a standard or predefined design.

How the effectiveness of the treatment is controlled
In a non placebo-controlled study, no participants receive an inert substance (placebo) to compare outcomes. Instead, all participants receive either the experimental treatment or an alternative treatment (often the Standard of Care). This method allows researchers to compare the effects of the experimental treatment with those of a different active intervention, rather than a placebo.

Other Options
Placebo-Controlled: A placebo is used to compare the effects of the experimental treatment with those of an inert substance, isolating the true treatment effect.

How the interventions assigned to participants is kept confidential
Everyone involved in the study knows which treatment is being given. This is typically used when it's not possible or necessary to hide the treatment details from participants or researchers.

Other Ways to Mask Information
Single-blind: Participants do not know which treatment they are receiving, but researchers do.
Double-blind: Neither participants nor researchers know which treatment is given.
Triple-blind: Participants, researchers, and outcome assessors do not know which treatment is given.
Quadruple-blind: Participants, researchers, outcome assessors, and care providers all do not know which treatment is given.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria
Any sexBiological sex of participants that are eligible to enroll.
Over 18 YearsRange of ages for which participants are eligible to join.
Healthy volunteers allowedIf individuals who are healthy and do not have the condition being studied can participate.
Criteria

Motivate Aim Inclusion Criteria: * Age 50 years or older * Self-identify as Latino/a/x and/or indigenous groups from Latin America * Eligible for RSV vaccination per current CDC/ACIP recommendations * Fluent in Spanish or English * Has not received the RSV vaccine * Has a cell phone * Lives or works in San Francisco or Daly City * Able to provide informed consent Motivate Aim Exclusion Criteria: * Intent to move outside of San Francisco or Daly City in the next year * Nursing home resident * Household member participating in Aim 1 or 2 * Unable to provide consent Motivate Aim Inclusion Criteria: * Age 18-49 years * Self-identify as Latino/a/x and/or indigenous groups from Latin America * Fluent in English or Spanish * Has \>1 family member or friend 50 years or older who they have seen or spoken to for \>15 minutes in the last 6 months and who lives in the United States Activate Trial Exclusion Criteria: * Household member enrolled in Aim 1 or 2 * Unable to provide consent

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives
4 intervention groups 

are designated in this study

This study does not include a placebo group 

Treatment Groups
Group I
Experimental

Participants receive both text message reminders and a counseling session, along with information about RSV and the vaccine, to encourage RSV vaccine uptake.
Group II
Active Comparator

Participants receive text message reminders along with information about RSV and the RSV vaccine to encourage vaccine uptake, but do not receive the counseling intervention
Group III
Experimental

Participants receive both text message reminders and a counseling session, along with information about RSV and the vaccine, to encourage discussion of RSV vaccine uptake among older adults in their social networks
Group IV
Active Comparator

Participants receive text message reminders along with information about RSV and the vaccine to encourage discussion of RSV vaccine uptake among older adults in their social networks, but do not receive the counseling intervention
Study Objectives
Primary Objectives

RSV vaccine uptake at 60 days per California Immunization Registry (CAIR) or per medical record

Self-reported average proportion of social network contacts 50 years or older with whom participant discussed RSV vaccination at 60 days

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.
This study has 1 location
Recruiting
University of California, San FranciscoSan Francisco, United StatesSee the location
Recruiting
One Study Center