PRISM-IBDSodium Impact on Inflammation in Crohn's Disease

This study explores how dietary sodium affects inflammation in people with Crohn's disease, a type of inflammatory bowel disease (IBD). The research is conducted in two phases. In the first phase, 300 individuals with Crohn's disease are monitored over two years to understand how sodium in their diet and enzymes in their stool relate to their disease activity. This information is gathered through regular health checks, questionnaires about their diet, and analysis of blood, stool, and urine samples. The goal is to create a comprehensive registry to better understand the factors that influence inflammation in Crohn's disease. In the second phase, a smaller group of 80 participants from the first phase continues with a more detailed study. These participants are divided into two groups based on their sodium intake—one high-sodium and one low-sodium. Over three weeks, they provide stool, blood, and urine samples to examine changes in gut bacteria and other metabolic markers. A colonoscopy is performed in the second week to directly observe the gut's condition. Throughout this phase, participants' diets are carefully tracked to assess the impact of sodium and other nutrients on their disease. This phase aims to provide deeper insight into how sodium consumption might influence the inflammation process in Crohn's disease.