Recruiting

PROMISEPrecision Tobacco Treatment for Smoking Cessation in Oncology Patients

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What is being tested

Usual care

+ Precision treatment

Behavioral
Who is being recruted

Behavior+1

+ Smoking

+ Health Behavior

From 18 to 89 Years
See all eligibility criteria
How is the trial designed

Prevention Study

Interventional
Study Start: September 2025
See protocol details

Summary

Principal SponsorWashington University School of Medicine
Study ContactLi-Shiun Chen, ScD, M.D., MPHMore contacts
Last updated: December 11, 2025
Sourced from a government-validated database.Claim as a partner

Study start date: September 11, 2025

Actual date on which the first participant was enrolled.

This study focuses on helping cancer patients quit smoking by using a personalized approach to tobacco treatment. The goal is to provide each patient with the most effective and safest smoking cessation medication tailored just for them. The study involves cancer patients and their doctors, aiming to improve how often doctors recommend and patients use these treatments. This approach is important because quitting smoking can significantly improve a cancer patient's quality of life and survival. By integrating this personalized treatment into cancer care, the study hopes to enhance the effectiveness of smoking cessation efforts. In the study, doctors and their cancer patients are divided into two groups: one receiving standard care and the other receiving the personalized precision treatment. This personalized treatment involves sharing specific risks, benefits, and treatment recommendations with each patient to encourage them to follow through with quitting smoking. The study measures success by looking at how many patients receive and use the tobacco treatments, as well as how many successfully quit smoking. Other aspects such as the patients' quality of life and survival are also monitored. The study also examines how the personalized approach influences both doctors' and patients' attitudes towards smoking cessation and the overall implementation of the treatment.

Official TitlePrecision Treatment to Promote Smoking Cessation and Survival in Oncology Patients 
NCT07166120
Principal SponsorWashington University School of Medicine
Study ContactLi-Shiun Chen, ScD, M.D., MPHMore contacts
Last updated: December 11, 2025
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

112 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Prevention Study

Prevention studies aim to stop a disease from developing. They often involve people at risk and test things like vaccines, lifestyle changes, or preventive medications.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 89 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

BehaviorSmokingHealth BehaviorSmoking Cessation

Criteria

Eligibility Criteria for Clinicians: * Clinician from participating oncology/hematology clinic * At least 18 years of age * Can speak and understand English Inclusion Criteria for Patients: * Patient at participating clinic * Age 18-89 years * Current smoking (average cigarettes per day ≥5) * Can speak and understand English * Willing to consider medication to help reduce craving or smoking such as nicotine patch, lozenge, or varenicline Exclusion Criteria for Patients: * Active use of smoking cessation medication (within the past 30 days) * Receipt of smoking cessation medication or prescription for smoking cessation medication (within the past 30 days) * Having a contradiction for cNRT or varenicline (allergic reactions, current cardiac problems, pregnancy) * Patients who were deemed by the investigator to be ineligible for participation in the trial

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Active Comparator
The arm will represent usual care in the oncology care clinics. Clinicians will receive a report designed to recommend guideline-based tobacco treatment. Patients will receive a report on guideline-based advice about smoking cessation and a brief discussion with a behavior interventionist.

Group II

Experimental
Clinicians will receive PrecisionTx-Onc, an intervention designed to recommend precision tobacco treatment, adapted for oncology. Patients will receive PrecisionTx-Onc, an intervention designed to recommend precision tobacco treatment, and a brief discussion with a behavior interventionist, adapted for oncology.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

Washington University School of Medicine

St Louis, United StatesSee the location
Recruiting
One Study Center