Completed

Levofloxacin vs Ciprofloxacin for Childhood Typhoid Fever

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Study Aim

This study aims to evaluate the effectiveness and safety of Levofloxacin compared to Ciprofloxacin in treating children with typhoid fever.

What is being tested

Levofloxacin

+ ciprofloxacin

Drug
Who is being recruted

Bacterial Infections and Mycoses+8

+ Bacterial Infections

+ Body Temperature Changes

From 1 to 12 Years
+9 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Treatment Study

Phase 2
Interventional
Study Start: February 2025
See protocol details

Summary

Principal SponsorAvicenna Medical College Lahore
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: February 7, 2025

Actual date on which the first participant was enrolled.

This study focuses on comparing the effectiveness of two antibiotics, Levofloxacin and Ciprofloxacin, in treating children with typhoid fever. Typhoid fever is a serious illness that affects many children, particularly in certain regions, and can cause prolonged high fever and other symptoms. The study aims to determine which of the two drugs is more effective in reducing the fever within a shorter time frame. By doing so, it hopes to improve treatment strategies for childhood typhoid fever, ultimately helping children recover more quickly and reducing the severity and duration of the illness. In this study, 360 children with typhoid fever are randomly assigned to receive one of the two drugs. One group receives a 200 mg oral dose of Levofloxacin, while the other group receives an oral dose of 900-1,000 mg of Ciprofloxacin. The children's fever is closely monitored for 7 days in a pediatric ward. The main goal is to see if the fever resolves within 5 days, meaning the child's body temperature drops below 99°F and stays stable for at least 5 days. The study records how long it takes for the fever to resolve in each child, providing valuable data on the effectiveness of each treatment.

Official TitleEfficacy of Levofloxacin Versus Ciprofloxacin in the Treatment of Childhood Typhoid Fever
NCT07150065
Principal SponsorAvicenna Medical College Lahore
Last updated: January 28, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

360 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 1 to 12 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Bacterial Infections and MycosesBacterial InfectionsBody Temperature ChangesEnterobacteriaceae InfectionsFeverInfectionsSalmonella InfectionsSigns and SymptomsPathological Conditions, Signs and SymptomsTyphoid FeverGram-Negative Bacterial Infections

Criteria

3 inclusion criteria required to participate
Children of age 1-12 years
Typhoid fever
Confirmed on blood culture
6 exclusion criteria prevent from participating
Recurrent typhoid within 3 months
Intestinal perforation
Evidence of progressive or complicated disease
Inability to swallow oral medication
Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Active Comparator
Group A included 180 participants. They were given oral 200 mg levofloxacin tablet. All children were followed-up pediatric wards for 7 days. If fever was resolved within 5 days (body temperature falls \<99oF and remain stable for at least 5 days), then efficacy was labeled. Total time required to resolve fever i.e. body temperature \<99oF in all children was also noted.

Group II

Active Comparator
. In group B, children were given oral 900-1,000 mg ciprofloxacin tablet. All children were followed-up pediatric wards for 7 days. If fever was resolved within 5 days (body temperature falls \<99oF and remain stable for at least 5 days), then efficacy was labeled. Total time required to resolve fever i.e. body temperature \<99oF in all children was also noted

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Suspended

Avicenna Hospital Lahore

Lahore, PakistanOpen Avicenna Hospital Lahore in Google Maps
CompletedOne Study Center