Stem Cell-Derived Exosome Therapy for Progressive Multiple Sclerosis

This clinical trial aims to determine if a new treatment using special particles called exosomes, derived from mesenchymal stem cells (MSC), can help people with progressive multiple sclerosis (MS). The study focuses on whether these exosomes can slow down the worsening of disabilities and enhance nerve function. It will also assess how safe and tolerable these exosome infusions are for participants. The trial targets adults living with progressive MS, a condition where symptoms gradually get worse, and aims to find ways to improve their quality of life and manage symptoms more effectively. Participants in the study will receive either the exosome treatment or a placebo, which is a harmless saline solution, through an intravenous infusion every three months for one year. The study will involve a series of assessments to track any changes in their condition. These include neurological exams, scoring of disability levels, and cognitive tests. Blood and spinal fluid samples will be collected to look for biological indicators of treatment effect. MRI scans will be used to check for changes in brain lesions and volume. Additionally, participants will fill out questionnaires about their quality of life and daily activities, providing a comprehensive view of how the treatment impacts their lives.